main quiescent or divide, and the researchers speculate that treatments to diminish MEF may improve recovery from chemotherapy and radiation. However, it is important to point out that while reduced expression of MEF might enhance recovery after myelosuppression, it is possible that certain leukemic stem cells may also be protected from these same treatments. "Myelotoxicity induced by chemotherapy or radiotherapy could be prevented by maintaining stem cells in a quiescent state during their administration to cancer patients. However, another implication of our work is that tumor stem cells are more quiescent than more differentiated tumor cells and could use similar mechanisms to resist the effects of chemotherapy or radiation," explains Dr. Nimer.

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Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
13-Mar-2006

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