Protein tied to usher syndrome may be hearing's 'Mis...( distributed in a specific way in relat...)

Protein tied to usher syndrome may be hearing's 'Missing Link'

distributed in a specific way in relation to the tip-link complex. They propose that the CD3 form of protocadherin-15, located at the tip of the shorter stereocilium, may link directly or indirectly to the CD1 form on the adjacent, taller stereocilium. This scenario could help explain how tip links that are broken in real-life situations, such as from excessive exposure to loud noise, could cause temporary hearing loss until the link re-establishes itself and hearing is restored.

In future studies, the scientists plan to delve more deeply into the role that protocadherin-15 plays in the tip-link complex and whether it interacts with other components in the formation of the tip link. They also hope to determine how tip links can be stimulated to re-form, once broken.

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Contact: Jennifer Wenger
jwenger@mail.nih.gov
301-496-7243
NIH/National Institute on Deafness and Other Communication Disorders
27-Jun-2006

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