HOME >> BIOLOGY >> NEWS
Proteins linked to cancer prevention in humans affect aging in worms

Novato, CA Proteins which prevent cancer in humans by ensuring that cells don't divide if they have chromosomal damage have been shown to determine lifespan in the nematode worm C. elegans. A Buck Institute study, appearing in the June 2nd issue of the journal Science, shows that checkpoint proteins, traditionally thought only to be functional in cells that divide, are also active in cells that no longer divide. The fact that the proteins appear to have dual functions opens a new way to study the connection between aging and cancer.

"Statistically, we know that aging is a huge risk factor for cancer," said Buck faculty member Gordon Lithgow, PhD, lead author of the study. "We don't know why that is. If we look at checkpoint proteins as a gear we've known for a long time that they drive the cancer gear, now we know that they also drive a longevity gear. This discovery has exciting potential as area of inquiry into a potential cellular link between aging and cancer."

The research carried out in the Buck Institute's Lithgow Laboratory, involved genetically eliminating checkpoint proteins in the microscopic worms. This caused a 15 30% increase in their lifespan. Given the role that checkpoint proteins play in preventing the development of cancer (or in encouraging it when the proteins are defective), the findings raise the question of whether genetic variations in checkpoint proteins in humans may place some individuals at risk for cancer, but protect them against other age-associated diseases; or conversely, set a genetic course for a shorter life which would be free from cancer.

The intriguing discovery came from ongoing work in the Lithgow lab, during a screening for genes that determine stress resistance and longevity in the worm, an animal which has about 18,000 genes and does not undergo cell division once it reaches maturity. Lead researcher Anders Olsen, PhD, found an unfamiliar gene during his screening. "I typed the DNA sequence int
'"/>

Contact: Kris Rebillot
krebillot@buckinstitute.org
415-209-2260
Buck Institute for Age Research
1-Jun-2006


Page: 1 2

Related biology news :

1. Proteins anchor memories in our brain
2. Proteins may behave differently in natural environments
3. Proteins may predict lung transplant rejection
4. Parallel evolution: Proteins do it, too
5. Proteins stop blood-vessel and tumor growth in mice
6. Proteins are key to cell death in heart disease, stroke and degenerative conditions
7. Proteins subtle backrub motion could have important implications
8. Proteins take on new roles in malaria parasite
9. Proteins link obesity, diabetes; May underlie systemic metabolic syndrome
10. Protein chatter linked to cancer activation
11. Risk of common vaginal infection linked to preterm birth appears higher for blacks

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Proteins linked cancer prevention humans affect aging worms

(Date:12/10/2014)...  Valencell, a leader in performance biometric data sensor ... from its licensees for highly accurate, clinically validated biometric ... coming from fitness and health sectors, but first responders/military ... is only as useful as the biometric data it ... in long-term mass consumer adoption of wearable products," said ...
(Date:12/10/2014)... 2014 Research and Markets ( ... "Biometrics Market in Japan 2014-2018" report ... http://photos.prnewswire.com/prnh/20130307/600769 The integration of biometrics ... banking and upgradation of the driver,s license is ... market. Besides the aforementioned projects, biometrics is being ...
(Date:12/5/2014)...  Tute Genomics, a leader in cloud-based solutions for ... funding led by UK-based Eurovestech. Peak Ventures and a ... round. "We are at a pivotal time ... and seeks new approaches for the diagnosis, treatment and ... MBA, and CEO of Tute Genomics. "One of the ...
Breaking Biology News(10 mins):Wearable Technology Products Demand Highly Accurate Biometric Technology 2Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3
(Date:12/19/2014)... Dec. 18, 2014  Decision Resources Group finds that ... market will grow moderately through 2023 as the aging ... awareness of dental biomaterials all spur procedure volumes. Growth ... China and India ... procedures within reach for a larger proportion of the ...
(Date:12/19/2014)... , Dec. 18, 2014   ISN ... & Safety Performance Indicators publication series. With ... of activity reported in 2013 within its online contractor ... and safety key performance indicator (KPI) statistics. ... Clients, U.S. publication is available in two ...
(Date:12/17/2014)... NY (PRWEB) December 16, 2014 The ... changes since 2013, which is why IBISWorld updated its ... industry continues to benefit from an intensified focus on ... proposal for new emission standards for power plants and ... operators. According to IBISWorld Industry Analyst Sarah Kahn, “a ...
(Date:12/17/2014)... Bellingham, Washington, USA (PRWEB) December 16, 2014 ... Kirstin Baum, manager at Philipps- Universität Marburg’s Department ... optics and photonics, in the newly released ... 2015-2016. “And never be too shy to ask ... STEM (science, technology, engineering, and mathematics) occupations ranging ...
Breaking Biology Technology:Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 3Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3
Cached News: