HOME >> BIOLOGY >> NEWS
Proteins linked to cancer prevention in humans affect aging in worms

Novato, CA Proteins which prevent cancer in humans by ensuring that cells don't divide if they have chromosomal damage have been shown to determine lifespan in the nematode worm C. elegans. A Buck Institute study, appearing in the June 2nd issue of the journal Science, shows that checkpoint proteins, traditionally thought only to be functional in cells that divide, are also active in cells that no longer divide. The fact that the proteins appear to have dual functions opens a new way to study the connection between aging and cancer.

"Statistically, we know that aging is a huge risk factor for cancer," said Buck faculty member Gordon Lithgow, PhD, lead author of the study. "We don't know why that is. If we look at checkpoint proteins as a gear we've known for a long time that they drive the cancer gear, now we know that they also drive a longevity gear. This discovery has exciting potential as area of inquiry into a potential cellular link between aging and cancer."

The research carried out in the Buck Institute's Lithgow Laboratory, involved genetically eliminating checkpoint proteins in the microscopic worms. This caused a 15 30% increase in their lifespan. Given the role that checkpoint proteins play in preventing the development of cancer (or in encouraging it when the proteins are defective), the findings raise the question of whether genetic variations in checkpoint proteins in humans may place some individuals at risk for cancer, but protect them against other age-associated diseases; or conversely, set a genetic course for a shorter life which would be free from cancer.

The intriguing discovery came from ongoing work in the Lithgow lab, during a screening for genes that determine stress resistance and longevity in the worm, an animal which has about 18,000 genes and does not undergo cell division once it reaches maturity. Lead researcher Anders Olsen, PhD, found an unfamiliar gene during his screening. "I typed the DNA sequence int
'"/>

Contact: Kris Rebillot
krebillot@buckinstitute.org
415-209-2260
Buck Institute for Age Research
1-Jun-2006


Page: 1 2

Related biology news :

1. Proteins anchor memories in our brain
2. Proteins may behave differently in natural environments
3. Proteins may predict lung transplant rejection
4. Parallel evolution: Proteins do it, too
5. Proteins stop blood-vessel and tumor growth in mice
6. Proteins are key to cell death in heart disease, stroke and degenerative conditions
7. Proteins subtle backrub motion could have important implications
8. Proteins take on new roles in malaria parasite
9. Proteins link obesity, diabetes; May underlie systemic metabolic syndrome
10. Protein chatter linked to cancer activation
11. Risk of common vaginal infection linked to preterm birth appears higher for blacks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced Design ... will feature emerging and evolving technology through its ... Summits will run alongside the expo portion of the ... panels and demonstrations focused on trending topics within 3D ... design and manufacturing event will take place June 13-15, 2017 ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, a ... authentication solutions, today announced that it has been ... Research Projects Activity (IARPA) to develop next-generation Presentation ... "Innovation has been a driving force ... program will allow us to innovate and develop ...
(Date:4/11/2017)... No two people are believed to ... York University Tandon School of Engineering and Michigan ... partial similarities between prints are common enough that ... and other electronic devices can be more vulnerable ... in the fact that fingerprint-based authentication systems feature ...
Breaking Biology News(10 mins):
(Date:4/25/2017)... ... April 25, 2017 , ... Leaders of Quorum Review IRB and ... multiple sessions at this week’s Association of Clinical Research Professionals (ACRP) 2017 Meeting ... clinical research. , "We are excited to present subject matter expertise on topics that ...
(Date:4/21/2017)... ... April 21, 2017 , ... Having worked on the design of the innovative ... introduce it to top lab design architects from around the country at the Lab ... Industrial Design and Engineering Greg Casey will be at the show, where they will ...
(Date:4/21/2017)... ... April 21, 2017 , ... Frederick Innovative Technology Center, Inc. ... bio and technology start-ups, is hosting “Celebration Friday” (a festive gathering highlighting client ... with libations and networking at 3:30 p.m. at FITCI’s 4539 Metropolitan Court location, ...
(Date:4/20/2017)... INDIANAPOLIS , April 20, 2017  Eli Lilly ... Phase 2 data evaluating galcanezumab for the prevention of ... meeting, which will take place April 22-28, 2017, in ... will present four abstracts at AAN, including safety and ... and factors associated with a reduction in monthly migraine ...
Breaking Biology Technology:
Cached News: