HOME >> BIOLOGY >> NEWS
Proteins linked to cancer prevention in humans affect aging in worms

Novato, CA Proteins which prevent cancer in humans by ensuring that cells don't divide if they have chromosomal damage have been shown to determine lifespan in the nematode worm C. elegans. A Buck Institute study, appearing in the June 2nd issue of the journal Science, shows that checkpoint proteins, traditionally thought only to be functional in cells that divide, are also active in cells that no longer divide. The fact that the proteins appear to have dual functions opens a new way to study the connection between aging and cancer.

"Statistically, we know that aging is a huge risk factor for cancer," said Buck faculty member Gordon Lithgow, PhD, lead author of the study. "We don't know why that is. If we look at checkpoint proteins as a gear we've known for a long time that they drive the cancer gear, now we know that they also drive a longevity gear. This discovery has exciting potential as area of inquiry into a potential cellular link between aging and cancer."

The research carried out in the Buck Institute's Lithgow Laboratory, involved genetically eliminating checkpoint proteins in the microscopic worms. This caused a 15 30% increase in their lifespan. Given the role that checkpoint proteins play in preventing the development of cancer (or in encouraging it when the proteins are defective), the findings raise the question of whether genetic variations in checkpoint proteins in humans may place some individuals at risk for cancer, but protect them against other age-associated diseases; or conversely, set a genetic course for a shorter life which would be free from cancer.

The intriguing discovery came from ongoing work in the Lithgow lab, during a screening for genes that determine stress resistance and longevity in the worm, an animal which has about 18,000 genes and does not undergo cell division once it reaches maturity. Lead researcher Anders Olsen, PhD, found an unfamiliar gene during his screening. "I typed the DNA sequence int
'"/>

Contact: Kris Rebillot
krebillot@buckinstitute.org
415-209-2260
Buck Institute for Age Research
1-Jun-2006


Page: 1 2

Related biology news :

1. Proteins anchor memories in our brain
2. Proteins may behave differently in natural environments
3. Proteins may predict lung transplant rejection
4. Parallel evolution: Proteins do it, too
5. Proteins stop blood-vessel and tumor growth in mice
6. Proteins are key to cell death in heart disease, stroke and degenerative conditions
7. Proteins subtle backrub motion could have important implications
8. Proteins take on new roles in malaria parasite
9. Proteins link obesity, diabetes; May underlie systemic metabolic syndrome
10. Protein chatter linked to cancer activation
11. Risk of common vaginal infection linked to preterm birth appears higher for blacks

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Proteins linked cancer prevention humans affect aging worms

(Date:8/12/2015)... CORAL SPRINGS, Florida , August 12, 2015 /PRNewswire/ ... globally, the pace of mobile payment innovation and advanced ... continues to replace the way consumers rely on using ... forges ahead with reinventing the future for payment services ... Inc. (NASDAQ: NXTD ), :  Google, Inc. (NASDAQ: ...
(Date:8/10/2015)... August 10, 2015 The latest 364 ... comprehensive analysis of the global border security market . ... of $16.4bn in 2015. Now: Border security is ... example of the business critical issue you need to know ... visiongain ,s objective analysis of how this will impact your ...
(Date:8/5/2015)... New York , August 5, 2015 ... market report titled "Facial Recognition Market - Global Industry ... 2022", the global market for facial recognition is forecast ... is driven by increased demand for surveillance systems by ... the rising number of crimes and terrorist activities across ...
Breaking Biology News(10 mins):Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 2Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 3Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 4Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 5Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 6Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 7Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 8Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 9Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 4Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 5Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 6
(Date:9/1/2015)... CARY, N.C. , Sept. 1, 2015 /PRNewswire/ ... dedicated to facilitating the relationship between doctors and ... two Durham, N.C. -based venture ... financial strength and business association with Bull City ... Steve Malik , Medfusion Founder and Executive Chairman. ...
(Date:9/1/2015)... ... September 01, 2015 , ... Research conducted by Synedgen ... Boston University School of Medicine, Frederick National Laboratory for Cancer Research, and the ... multidisciplinary Open Access journal. , Christopher Ryan PhD, of Synedgen, and Aparajita ...
(Date:8/31/2015)... ... August 31, 2015 , ... The Global Supply Chain ... management and resiliency practitioners with luminaries and thought leaders to advance the professional ... for their innovations and performance excellence. At that time its principle sponsor, ...
(Date:8/31/2015)... SAN DIEGO , Aug. 31, 2015 ... drug development company announces that the Company,s lead antibody, ... subject of five separate presentations during the upcoming World ... Hawaii September 2-5, 2015. Researchers from the ... (MSK) will present results on the use of MabVax,s ...
Breaking Biology Technology:Medfusion Secures Funding to Continue Evolution and Advance Mobile Strategy 2Medfusion Secures Funding to Continue Evolution and Advance Mobile Strategy 3Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 2Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 3Global Supply Chain Resiliency Council Announces Incorporation and Web Site Launch 2Global Supply Chain Resiliency Council Announces Incorporation and Web Site Launch 3MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 2MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 3MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 4
Cached News: