HOME >> BIOLOGY >> NEWS
Proteins take on new roles in malaria parasite

While searching for new targets for malaria drugs and vaccines, a team including a Howard Hughes Medical Institute (HHMI) medical student fellow reached a fundamental insight about evolution: different species make use of similar sets of proteins in different ways.

"We've observed that organisms may share many similar proteins and yet retain very little parallel function among them," said Taylor Sittler, a medical student at the University of Massachusetts Medical School in Worcester, Massachusetts. "For instance, Plasmodium falciparum--the parasite that causes malaria--shares with its human host many proteins involved in forming chromosomes during cell division, but those proteins may interact in different ways, creating different cellular pathways and even entirely different functions. This contradicts the currently accepted paradigm that shared proteins interact simply because their genes are conserved. It was quite unexpected," he added.

Malaria is the third leading cause of infectious disease death in the world, after tuberculosis and AIDS. The World Health Organization estimates the parasite causes acute illness in some 300 million people each year, resulting in about 2.7 million deaths.

Sittler, who conducted the research during his HHMI fellowship year at the University of California at San Diego (UCSD), is co-first author on a paper published in the November 3, 2005, issue of the journal Nature. The paper was co-authored by two UCSD colleagues, Silpa Suthram, a Ph.D. candidate in bioinformatics, and Trey Ideker, an assistant professor of bioengineering.

The team made the discovery while comparing protein networks of P. falciparum to protein networks in four model organisms: yeast, fruit flies, roundworms, and Helicobacter pylori, the bacteria that causes stomach ulcers. Their analysis drew on data developed by HHMI investigator Stanley Fields, a professor of genetics and yeast genome expert at the University of Washington
'"/>

Contact: Jennifer Donovan
donovanj@hhmi.org
301-215-8859
Howard Hughes Medical Institute
2-Nov-2005


Page: 1 2 3 4

Related biology news :

1. Proteins anchor memories in our brain
2. Proteins may behave differently in natural environments
3. Proteins may predict lung transplant rejection
4. Parallel evolution: Proteins do it, too
5. Proteins linked to cancer prevention in humans affect aging in worms
6. Proteins stop blood-vessel and tumor growth in mice
7. Proteins are key to cell death in heart disease, stroke and degenerative conditions
8. Proteins subtle backrub motion could have important implications
9. Proteins link obesity, diabetes; May underlie systemic metabolic syndrome
10. ORNL researchers, supercomputer have large roles in DOE projects
11. Sunflower speciation highlights roles for transposable elements in evolution

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Proteins take new roles malaria parasite

(Date:11/5/2014)... RENO – Kelly Redmond has dedicated his career ... knowledge to a general audience. , As deputy ... Climate Center at Nevada,s Desert Research Institute, Redmond ... the management, application and dissemination of climate data ... Annual Fall Meeting in San Francisco on December ...
(Date:11/4/2014)... about the way our bodies are assembled during early ... they are supposed to become a nerve or a ... correct place and alignment? Researchers at the University of ... a new study, UM researchers describe the signaling systems ... at the head-trunk region. Their discovery may have important ...
(Date:11/3/2014)... Research and Markets has announced the ... Markets and Companies" to their offering. ... which have already started to play an important role in ... the old fashioned bone marrow transplants. Role of cells in ... become a part of medical practice. Stem cells ...
Breaking Biology News(10 mins):Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2The inside story: How the brain and skull stay together 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3
(Date:11/26/2014)... The North America Thermal Protective Clothing Market ... analysis of the growth trends and revenue forecasts. ... by 2018, growing at a CAGR of 7.1% ... TOC of the North America Thermal Protective Clothing ... in-depth analysis and industry segmentation supported by various ...
(Date:11/26/2014)... YORK , Nov. 26, 2014 The ... may indicate the company is looking to expand in ... further sales.  The healthcare market research firm says that  ... to Kalorama Information,s biennial survey of the IVD market ... and any change in its composition would likely affect ...
(Date:11/26/2014)... , Nov. 26, 2014 The ... results from a survey of European physicians at ... on Innovation and Biological Therapies" at the Spanish ... event, hosted by EuropaBio and the Spanish Bioindustry ... of Health, physicians from Spanish oncology and rheumatology ...
(Date:11/26/2014)... The ETC (Emerging Technology Centers) ... announced today that applications for AccelerateBaltimore™ (AB) 2015 ... you have a big idea?,” asked ETC’s President ... about it. AccelerateBaltimore helps you and your big ... 13 weeks.” Interested game changers with “big ...
Breaking Biology Technology:The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 2The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 3Kalorama: Sale of Three Siemens Healthcare Units Raises Questions About Firm's IVD Future 2ASBM Presents European Physicians Survey at Spanish Ministry of Health 2AccelerateBaltimore Applications to Close in 6 Days 2AccelerateBaltimore Applications to Close in 6 Days 3
Cached News: