HOME >> BIOLOGY >> NEWS
Proteins take on new roles in malaria parasite

While searching for new targets for malaria drugs and vaccines, a team including a Howard Hughes Medical Institute (HHMI) medical student fellow reached a fundamental insight about evolution: different species make use of similar sets of proteins in different ways.

"We've observed that organisms may share many similar proteins and yet retain very little parallel function among them," said Taylor Sittler, a medical student at the University of Massachusetts Medical School in Worcester, Massachusetts. "For instance, Plasmodium falciparum--the parasite that causes malaria--shares with its human host many proteins involved in forming chromosomes during cell division, but those proteins may interact in different ways, creating different cellular pathways and even entirely different functions. This contradicts the currently accepted paradigm that shared proteins interact simply because their genes are conserved. It was quite unexpected," he added.

Malaria is the third leading cause of infectious disease death in the world, after tuberculosis and AIDS. The World Health Organization estimates the parasite causes acute illness in some 300 million people each year, resulting in about 2.7 million deaths.

Sittler, who conducted the research during his HHMI fellowship year at the University of California at San Diego (UCSD), is co-first author on a paper published in the November 3, 2005, issue of the journal Nature. The paper was co-authored by two UCSD colleagues, Silpa Suthram, a Ph.D. candidate in bioinformatics, and Trey Ideker, an assistant professor of bioengineering.

The team made the discovery while comparing protein networks of P. falciparum to protein networks in four model organisms: yeast, fruit flies, roundworms, and Helicobacter pylori, the bacteria that causes stomach ulcers. Their analysis drew on data developed by HHMI investigator Stanley Fields, a professor of genetics and yeast genome expert at the University of Washington
'"/>

Contact: Jennifer Donovan
donovanj@hhmi.org
301-215-8859
Howard Hughes Medical Institute
2-Nov-2005


Page: 1 2 3 4

Related biology news :

1. Proteins anchor memories in our brain
2. Proteins may behave differently in natural environments
3. Proteins may predict lung transplant rejection
4. Parallel evolution: Proteins do it, too
5. Proteins linked to cancer prevention in humans affect aging in worms
6. Proteins stop blood-vessel and tumor growth in mice
7. Proteins are key to cell death in heart disease, stroke and degenerative conditions
8. Proteins subtle backrub motion could have important implications
9. Proteins link obesity, diabetes; May underlie systemic metabolic syndrome
10. ORNL researchers, supercomputer have large roles in DOE projects
11. Sunflower speciation highlights roles for transposable elements in evolution

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Proteins take new roles malaria parasite

(Date:4/15/2014)... Biologists at UC San Diego have succeeded in ... hormone responsible for growth and resistance to drought. ... studies to determine how the hormone helps plants ... by the continuing increase in the atmosphere,s carbon ... achievement appears in the April 15 issue of ...
(Date:4/15/2014)... Looking at the question of how social behavior has ... universities in Mainz and Basel have gained new insights ... simply compete for food. Rather the siblings share what ... absent," explained Dr. Jol Meunier of the Evolutionary Biology ... University of Mainz (JGU). The team of biologists from ...
(Date:4/15/2014)... (April 15, 2014) The American Association of Anatomists ... All awards will be presented during the Closing ... Hotel on Tuesday, April 29th at 7:30 p.m. during ... , The 2014 award winners are: , ... PhD, of the Icahn School of Medicine at Mount ...
Breaking Biology News(10 mins):Biologists develop nanosensors to visualize movements and distribution of plant hormone 2Sibling cooperation in earwig families gives clues to early evolution of social behavior 2American Association of Anatomists 2014 award winners 2
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
Cached News: