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Providence health system shows investigational osteoporosis therapy increases bone mineral density

compared with a decrease of 0.8 percent with placebo (p<0.001). Researchers also observed significant increases in BMD in the total hip from 1.9 to 3.6 percent in women who received denosumab compared with a decrease of 0.6 percent in the placebo group (p<0.001).

Across all doses and dosing intervals, distal 1/3 radius BMD increased from 0.4 to 1.3 percent with denosumab while BMD decreased by 2.0 percent in the placebo group (p<0.001), and total body BMD increased from 0.6 to 2.8 percent as compared with a decrease of 0.2 percent with placebo (p<0.01). Results also indicated that denosumab had a rapid onset of action, inhibiting the action of osteoclasts within 72 hours. According to Dr. McClung, "The ability to control bone metabolism and increase BMD so effectively with such a convenient dosing regimen shows a potential advantage of this therapeutic strategy over current therapies."

The incidence of adverse events was similar among the denosumab, placebo, and Fosamax groups.


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Contact: Paula Gunness
paula.gunness@providence.org
503-215-6433
Porter Novelli
22-Feb-2006


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