HOME >> BIOLOGY >> NEWS
Prozac's target revealed

Researchers at Cold Spring Harbor Laboratory on Long Island have identified which among several different kinds of cells in the brain is the chief target of the widely prescribed antidepressant Prozac. This discovery might enable a new generation of more specific treatments for depression, with fewer side effects, to be developed.

The findings also lay the foundation for many studies of the factors that control how, when, and where new neurons are generated from stem cells in the brain. Such work could eventually lead to cell replacement therapies for neurodegenerative and other brain disorders including Alzheimer's and Parkinson's disease.

It has been known for some years that Prozac (fluoxetine) is likely to relieve the symptoms of depression by somehow causing more neurons to be present in a particular region of the brain (the "dentate gyrus"). But the origins of these neurons, and how Prozac promotes their existence, have been a mystery until now.

By profiling the telltale marker proteins produced by different kinds of cells in the brains of adult mice, the researchers first defined discrete steps in the complex process, called neurogenesis, that converts unspecialized stem cells into mature, specialized neurons.

Next, knowing that Prozac treatment somehow increases the number of neurons in the brain, the researchers tested which step in the neurogenesis pathway might be stimulated by Prozac. They found that Prozac treatment specifically stimulates the generation of a kind of cells they dubbed "amplifying neural progenitors" or ANPs--the second step in the neurogenesis pathway from stem cells to mature neurons. (Illustration available on request)

The study is published in the published in the Proceedings of the National Academy of Sciences (advance on-line this week, in print on May 23). It was led by Grigori Enikolopov and spearheaded by postdoctoral fellow Juan Manuel Encinas.

To address the controversy surroundi
'"/>

Contact: Peter Sherwood
sherwood@cshl.edu
516-367-6947
Cold Spring Harbor Laboratory
15-May-2006


Page: 1 2

Related biology news :

1. Huntingtons disease study shows animal models on target
2. New target for HIV/AIDS drugs and vaccine discovered
3. When off-target is right on
4. Genomic analysis uncovers new targets for HIV vaccine
5. Bulls-eye -- Programs targeting math, science teacher shortage may get boost
6. Scientists take next step in understanding potential target for ovarian cancer treatment
7. On target
8. New way to target and kill antibiotic-resistant bacteria found
9. Weill Cornell team identifies potential new cancer drug target
10. CSHL scientists successfully target tumor microenvironment to stop cancer growth
11. Sleep deprivation affects airport baggage screeners ability to detect rare targets

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2018)... ... 13, 2018 , ... Career fairs provide an ideal setting ... systems at once. However, healthcare professionals often have hectic schedules with little spare ... healthcare providers who wish to explore opportunities and learn about multiple employers from ...
(Date:8/14/2018)... , ... August 13, 2018 , ... ... products, the Staticmaster® P-2021-5502 and P-2021-5602 Cleanroom Ionizing Gun. , The ionizing ... Nitrogen Air Gun, P-2021 ionizing cartridge, 0.5-micron filter and electropolished OSHA-compliant tip. This ...
(Date:8/14/2018)... Fla. (PRWEB) , ... August 14, 2018 , ... ... activity and sleep monitoring solutions for the global scientific community, announced today the ... focus of this new division is to foster and support scientific collaborations with ...
Breaking Biology News(10 mins):
(Date:8/9/2018)... ... August 08, 2018 , ... InTouchMD , the ... announced that they will be exhibiting at Biotech Week Boston , September 4th ... showcasing its Pulse platform, healthcare’s most powerful all in one marketing solution. ...
(Date:8/7/2018)... ... August 06, 2018 , ... Slone Partners, North America’s ... of Dr. Paul Harney as President, North America at Prescient Healthcare Group. Dr. ... client satisfaction. He was also named to Prescient’s Board of Directors. , ...
(Date:7/31/2018)... ... July 31, 2018 , ... ... years, announces the launch of their new website. The new website has been ... the site. Mahoney partnered with Proceed Innovative to build a website created for ...
(Date:7/25/2018)... MATEO, Calif. (PRWEB) , ... July 25, 2018 ... ... for in vivo research utilizing its state-of-the-art Digital Vivarium™ and Vium Cloud approach ... Schaevitz, Ph.D., to Chief Scientific Officer. Additionally, the company announced the appointment of ...
Breaking Biology Technology:
Cached News: