HOME >> BIOLOGY >> NEWS
Purdue scientists hunt for 'secret X' to treat liver cancer

WEST LAFAYETTE, Ind. - Identifying the link between chronic hepatitis B infection and liver cancer may one day help cancer patients sidestep the poison of chemotherapy, a Purdue University study suggests.

The research group of Ourania M. Andrisani (oo-RAHN-ee-ah an-dri-SAH-nee) has shown that a protein the hepatitis virus instructs chronically infected liver cells to produce - known as the X protein - under certain conditions instructs precancerous infected liver cells to die. The discovery of how the X protein influences liver cell behavior could be harnessed as an anticancer therapy, turning the X protein's presence in the liver to patients' advantage.

"Instead of chemotherapy, drugs that influence the X protein's behavior might become an alternative cancer therapy," said Andrisani, a professor of basic medical sciences in Purdue's School of Veterinary Medicine. "Rather than give a patient chemicals that damage every cell in the body, therapy based on the X protein could potentially target only cancerous cells, slowing their growth."

The research, which Andrisani conducted with first author Wen Horng Wang, and Grald Gregori and Ronald L. Hullinger, all of Purdue, appears in the current issue of Molecular and Cellular Biology.

Viruses like the hepatitis B virus incorporate their genes into a healthy cell's genetic material. This way, many viruses not only instruct the cell to make proteins necessary to assemble more virus particles, but they also change or deregulate the normal production of proteins by the healthy cell. One of the genes hepatitis B introduces into liver cells is called the X gene, a short sequence of DNA that "expresses," or creates, the X protein - a building block essential for creating hepatitis B. Scientists have suspected the gene and its corresponding protein to be accomplices in cancer development as well.

"The X protein is present in the livers of all chronic hepatitis B patients, and sev
'"/>

Contact: Chad Boutin
cboutin@purdue.edu
765-494-2081
Purdue University
13-Dec-2004


Page: 1 2 3

Related biology news :

1. Purdue-IU researchers explore new method for early disease diagnosis
2. Alzheimers drug based on Purdue -- designed inhibitor begins clinical trials
3. NIH selects Purdue to use phi29 DNA packaging motor for National Nanomedicine Development Center
4. IU, Purdue selected for major NCI biomarker tools initiative
5. Purdue creates new low-cost system to detect bacteria
6. Industry, C-SPAN leaders energize Lugar-Purdue summit
7. Purdue researchers find switch for skeletal-muscle atrophy
8. Purdue project could help pets serve as disease watchdogs
9. Purdue biologists clarify how a cellular spacecraft opens its airlock
10. Purdue scientists see biochemistrys future - with quantum physics
11. Purdue scientists treat cancer with RNA nanotechnology

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2019)... , ... August 20, 2019 , ... ... and commercialization of bioactive technologies for the spine, today announced the 510(K) clearance ... a unique surface modification that is proven to improve osseointegration through superior hydrophilicity ...
(Date:8/15/2019)... TORONTO (PRWEB) , ... August 15, 2019 , ... ... finally passed. Now what? As serialization mandates become increasingly complex, and aggregation becomes ... their current serialization software is the best long-term solution. , Until now, most ...
(Date:8/14/2019)... ... ... Join Jonathan Riek, PhD, VP, Musculoskeletal & Metabolic Imaging, BioTel Research ... EDT to learn about two common imaging methods in NAFLD/NASH to aid with early ... diffuse liver disease, with a worldwide prevalence of 20-46 percent. NAFLD can be subdivided ...
Breaking Biology News(10 mins):
(Date:9/17/2019)... , ... September 16, 2019 , ... ... via CNBC on Saturday, September 21st @11:00am ET. Check local listings for more ... Ltd. (Credo Biomedical), a molecular diagnostic company from Singapore dedicated to developing ...
(Date:9/11/2019)... ... September 10, 2019 , ... Catalent, the leading global provider ... and consumer health products, today announced that Alex Haig, Senior Director, Engineering will ... AG, Schwabisch Hall, Germany, on Sept. 18-19, 2019. , On Wednesday, Sept. 18 ...
(Date:9/2/2019)... , ... September 02, 2019 , ... ... and in vitro diagnostics, has launched the industry’s first epigenetics data mining services ... meaning of epigenetic data and other data types. , Next generation sequencing in ...
(Date:8/27/2019)... HOUSTON (PRWEB) , ... August 27, 2019 , ... ... chain engineering firm, is pleased to announce it has promoted Consulting Engineer, Robert ... Solutions, Battista has added the responsibility of onboarding and mentoring new engineers as ...
Breaking Biology Technology:
Cached News: