HOME >> BIOLOGY >> NEWS
Rapamycin shown to inhibit angiogenesis

BOSTON Scientists have long known that the blood vessels of tumors differ markedly from normal blood vessels. Now, a research team led by scientists at Beth Israel Deaconess Medical Center (BIDMC) has identified a signaling pathway which, when activated, transforms otherwise healthy blood vessels into the leaky, misshapen vasculature that characterizes cancerous tumors.

The findings, published in the August 2006 issue of Cancer Cell, additionally demonstrate that rapamycin, a compound used for immunosuppression in transplant patients and currently under investigation as a cancer treatment, can successfully block this signaling pathway--known as the Akt pathway-- in blood vessels. This discovery further enhances the drug's promise as a cancer therapy.

"There are three major hallmarks associated with tumor blood vessels," explains the study's senior author Laura Benjamin, PhD, an investigator in BIDMC's Department of Pathology and Associate Professor of Pathology at Harvard Medical School.

"First, unlike healthy blood vessels which are uniform in structure, a tumor's blood vessels balloon and narrow, forming a highly irregular shape. Second, the layer of smooth muscle that you would expect to find covering the blood vessels is inadequate, often resulting in only intermittent coverage. And last, a tumor's blood vessels are overly permeable or leaky."

The hypothesis that blood vessel formation in tumors is essential for the growth and spread of cancer was first proposed in the early 1970's, and in 1983, it was shown that tumors secrete a factor called VEGF (vascular endothelial growth factor) that induces the permeability associated with blood vessels in cancer.

In this new study, Benjamin and first author Thuy Phung, MD, PhD, of BIDMC's Department of Pathology, hypothesized that the Akt pathway was mediating many of the functions of VEGF in tumors, including the stimulation of blood vessels with abnormal struct
'"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
14-Aug-2006


Page: 1 2 3

Related biology news :

1. Human-like altruism shown in chimpanzees
2. Insulin therapy shown to treat early experimental diabetic retinopathy
3. Gene test shown to measure heart function after transplant
4. Remicade therapy shown to improve productivity in patients treated for chronic plaque psoriasis
5. Active ingredient in common Chinese herb shown to reduce hypertension
6. Protein shown to rally biological clock
7. LouseBuster instrument shown to kill head lice
8. Vaccine shown effective against chancroid
9. First direct mechanical communication of mitochondria, cardiomyocyte nucleus shown
10. Reactive oxygen species shown essential for development of inner ears balance machinery
11. GlaxoSmithKlines rotavirus vaccine candidate shown effective

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2017)... April 17, 2017 NXT-ID, Inc. (NASDAQ: ... the filing of its 2016 Annual Report on Form 10-K on ... ... is available in the Investor Relations section of the Company,s website ... SEC,s website at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... Fla. , April 11, 2017 ... and secure authentication solutions, today announced that it ... Intelligence Advanced Research Projects Activity (IARPA) to develop ... Thor program. "Innovation has been a ... IARPA,s Thor program will allow us to innovate ...
(Date:4/11/2017)... April 11, 2017 NXT-ID, Inc. (NASDAQ: ... company, announces the appointment of independent Directors Mr. Robin ... its Board of Directors, furthering the company,s corporate governance and ... Gino Pereira ... look forward to their guidance and benefiting from their considerable ...
Breaking Biology News(10 mins):
(Date:6/26/2017)... ... ... Two new members were elected to the University City Science Center’s Board ... J Nowak Strategy and Michele Masucci, Ph.D., Vice President for Research Administration at Temple ... Kenneth L. Kring, and re-election of David P. Holveck and Richard P. Jaffe, as ...
(Date:6/23/2017)... Ringle, WI (PRWEB) , ... ... ... MedJobCafe.com announce the launch of a redesigned, easier-to-navigate website for all six ... job boards for physicians, nurses, dentists, pharmacists, physical and occupational therapists, and ...
(Date:6/22/2017)... , ... June 21, 2017 , ... Building on the ... inspiring, and more informative on the very latest developments in radical life extension. RAADfest ... of a festival, and the empowerment of personal development, making it the largest most ...
(Date:6/22/2017)... Prussia, PA (PRWEB) , ... June 22, 2017 ... ... knowledge and superior results to clients throughout the biopharma and life sciences industries, ... changes the industry is seeing. Tunnell’s Kip Wolf will be speaking on “The ...
Breaking Biology Technology:
Cached News: