HOME >> BIOLOGY >> NEWS
Reactivated gene shrinks tumors

CAMBRIDGE, Mass. -- Many cancers arise due to defects in genes that normally suppress tumor growth. Now, for the first time, MIT researchers have shown that re-activating one of those genes in mice can cause tumors to shrink or disappear.

The study offers evidence that the tumor suppressor gene p53 is a promising target for human cancer drugs.

"If we can find drugs that restore p53 function in human tumors in which this pathway is blocked, they may be effective cancer treatments," said David Kirsch of MIT's Center for Cancer Research and Harvard Medical School, one of the lead co-authors of the paper.

The study will be published in the Jan. 24 online edition of Nature. It was conducted in the laboratory of Tyler Jacks, director of the Center for Cancer Research, the David H. Koch Professor of Biology and a Howard Hughes Medical Institute investigator.

P53 has long been known to play a critical role in the development of many tumors-it is mutated in more than 50 percent of human cancers. Researchers have identified a few compounds that restore p53 function, but until now, it has not been known whether such activity would actually reverse tumor growth in primary tumors.

The new MIT study shows that re-activating p53 in mouse tumors dramatically reduces the size of the tumors, in some cases by 100 percent.

"This study provides critical genetic evidence that continuous repression of a tumor suppressor gene is required for a tumor to survive," said Andrea Ventura, an Italian postdoctoral associate in the Center for Cancer Research and first author of the paper.

In normal cells, p53 controls the cell cycle. In other words, when functioning properly, it activates DNA repair mechanisms and prevents cells with damaged DNA from dividing. If DNA damage is irreparable, p53 induces the cell to destroy itself by undergoing apoptosis, or programmed cell death.

When p53 is turned off by mutation or
'"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
24-Jan-2007


Page: 1 2 3

Related biology news :

1. Chemotherapy drug shrinks brain tumors
2. Overfishing large sharks impacts entire marine ecosystem, shrinks shellfish supply
3. Brains fear center likely shrinks in autisms most severely socially impaired
4. Ultrasounds show mothers drinking shrinks fetal brain
5. Melatonin shrinks bird gonads. What does the popular supplement do in humans?
6. Invasion of the brain tumors
7. A friendly foe -- Bacteria residing in the gut boost immune response to tumors
8. Nanoparticles carry chemotherapy drug deeper into solid tumors
9. Frog molecule could provide drug treatment for brain tumors
10. Study could impact noninvasive treatment of cancer tumors
11. Talcum powder stunts growth of lung tumors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... DAL ) customers now can use fingerprints instead of their boarding ... ... biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in May at the ... to allow eligible Delta SkyMiles Members who are enrolled in CLEAR to ...
(Date:6/14/2017)... -- IBM (NYSE: IBM ) is introducing several innovative partner ... developing collaboration between startups and global businesses, taking place in ... event, nine startups will showcase the solutions they have built ... France is one of ... 30 percent increase in the number of startups created between ...
(Date:5/16/2017)...   Bridge Patient Portal , an enterprise ... EMR Systems , an electronic medical record solutions ... established a partnership to build an interface between ... Centricity™ products, including Centricity Practice Solution (CPS), Centricity ... new integrations will allow healthcare delivery networks using ...
Breaking Biology News(10 mins):
(Date:8/23/2017)... ... August 22, 2017 , ... ... two market innovators, Munich Re , one of the world’s leading reinsurers ... strategic investor that accelerates the development of technologies to support the U.S. intelligence ...
(Date:8/23/2017)... ... 2017 , ... Heidelberg Instruments GmbH, leading supplier of maskless ... Generators from two major Asian based phtotomask production groups. , The breakthrough VPG+ ... well as a solution for mid volume direct write lithography applications. It utilizes ...
(Date:8/22/2017)... Waxhaw, NC (PRWEB) , ... August 22, 2017 ... ... device company focused on the development and distribution of highly differentiated spinal implant ... Luke Maher brings 15 years of spinal device industry experience to ...
(Date:8/21/2017)... (PRWEB) , ... August 20, 2017 , ... ... Journal of Biomedical Optics (JBO) starting 1 January 2018. The journal is published ... Biomedical Optics publishes papers on the use of modern optical technology for improved ...
Breaking Biology Technology:
Cached News: