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Recombination protein dynamics observed with single monomer resolution

hnique revealed intricate details of how RecA nucleates to form a filament, how the filament changes shape, and how the filament removes proteins from DNA.

"Contrary to our initial expectations, both ends of the RecA filament continually grow and shrink, but a higher binding rate at one end causes the filament to grow primarily in one direction," Ha said. "We also learned that as the filament grows and shrinks, it does so by one protein unit at a time."

Following recombination proteins step by step could further help researchers determine in what ways cancer-causing proteins are defective, and perhaps find ways to correct them.


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Contact: James E. Kloeppel
kloeppel@uiuc.edu
217-244-1073
University of Illinois at Urbana-Champaign
10-Aug-2006


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