Reconstructed 1918 influenza virus induces immune response that fails to protect

NEW YORK, New York, September 27, 2006--An analysis of mice infected with the reconstructed 1918 influenza virus has revealed that although the infection triggered a very strong immune system response, the response failed to protect the animals from severe lung disease and death. The study which was published by Mount Sinai researchers, working in collaboration with scientists from the University of Washington School of Medicine in Seattle, the Centers for Disease Control and Prevention, and the Armed Forces Institute of Pathology, appeared in the online edition of Nature on September 27.

"This study gives scientists new insight into how highly pathogenic influenza viruses, such as the 1918 Spanish flu, cause disease," says Christopher F. Basler, PhD, Assistant Professor of Microbiology, who collaborated with Peter Palese, PhD, the Horace W. Goldsmith Professor and Chair of Microbiology, and also Professor of Medicine and Adolfo Garcia-Sastre, PhD, Professor of Microbiology.

Members of the research team, many of whom had collaborated on the reconstruction of the 1918 influenza virus, wanted to know why the virus, which killed 20 to 40 million people, was so lethal. In the study, researchers infected one group of mice with the reconstructed 1918 influenza virus and a second group with benign human influenza. The mice infected with the 1918 virus showed a rapid and potent immune system response, yet the animals also developed severe lung disease and died. The animals infected with the more benign viruses did not develop an immune response that was as strong, and fewer of these animals died. Genes were expressed from lung tissue samples taken from the mice, enabling the researchers to trace the immune response to each of the infections.

The potent immune system reaction of the mice infected with the 1918 virus is one of the main questions raised by the study, according to Dr. Basler. Did the very strong immune system response contribute

Contact: Mount Sinai Press Office
The Mount Sinai Hospital / Mount Sinai School of Medicine

Page: 1 2

Related biology news :

1. Reconstructed 1918 flu virus providing insights for potential pandemics
2. Detecting transmissibility of avian influenza virus in human households
3. University of Colorado licenses two influenza virus detection discoveries to Quidel Corp.
4. Avian influenza survivors antibodies effective at neutralising H5N1 strain
5. New host species for avian influenza identified
6. NIH establishes Center of Excellence for influenza research at Mount Sinai
7. U OF M awarded $22.5 million NIH contract to study avian influenza
8. A first glimpse of the influenza replication machine
9. 2,000 influenza virus genomes now completed and publicly accessible
10. Fighting influenza and co. with 40,000 blood samples
11. Changes in amino acids in the 1918 influenza virus cut transmission

Post Your Comments:

(Date:6/11/2019)... ... 10, 2019 , ... Improved Pharma LLC announces the publication of “Predictive and ... The article was published online on April 29th, 2019. The authors are Stephen ... Chen of Purdue University. , The article is the most recent addition to a ...
(Date:6/4/2019)... JOSE, Calif. (PRWEB) , ... June 04, 2019 ... ... analytical technologies, today announced the appointment of Susan Murphy as the new President ... Coulter Life Sciences?owned by Molecular Devices’ parent company, Danaher Corporation. , Since joining ...
(Date:6/1/2019)... ... May 31, 2019 , ... The University of Vermont ... in BioFactura’s $6M Series B Financing Round. , “With the commitment from ... bring significant financial and business resources to bear as we advance our biopharmaceutical ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 29, 2019 , ... ... interest to our methodology, processes, and diagnostic techniques. The patent applications titled ... IP rights including our proprietary sleep scoring methodology. The approval and success ...
(Date:5/21/2019)... Ethiopia (PRWEB) , ... May 21, 2019 , ... ... Brauerei in Berlin (VLB) today officially opened the inaugural Africa Brewing Conference dedicated ... and malting industry in Africa. The event, which is supported through a partnership ...
(Date:5/8/2019)... ... 07, 2019 , ... Standing at 16.2 hands, Atlas is on the large side for a ... and barrel racing, among other activities. When loping around a corner in late 2017, ... a busy horse to only being able to walk. Fortunately Atlas’ owner, Kelly, sought ...
(Date:5/2/2019)... RAPID CITY, S.D. (PRWEB) , ... April 30, 2019 , ... ... of society, from industrial scale macro breweries to local craft breweries, and even home ... scale, involves very complex chemical and biological processes, that when mastered can produce a ...
Breaking Biology Technology:
Cached News: