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Red wine mist? Resveratrol shows potential effects against COPD, asthma, arthritis

BETHESDA, Md. (October 28, 2004) Homing in on mechanisms for the reported effectiveness of resveratrol, which is found in red wine, researchers at Imperial College London, England, confirmed its broad anti-inflammatory action, and found potential for applications in chronic obstructive pulmonary disease (COPD), asthma, and possibly even arthritis. Clinical preparation and delivery remain issues, though an aerosol version would have obvious benefits.

Indeed, lead researcher Louise Donnelly said "Resveratrol exhibited anti-inflammatory activity in all the systems we examined: laboratory cells lines as well as 'real' human airway epithelial cells," or HAEC. The research paper published by Donnelly et al. in the American Journal of Physiology-Lung Cellular and Molecular Physiology, notes: "Our study is novel as it examines the anti-inflammatory mechanism(s) of resveratrol in cells relevant to human disease and explores all of the proposed mechanisms in a single study."

Most importantly, resveratrol "inhibited anti-inflammatory mediator release from human airway epithelial cells." And contrary to earlier conjecture, the Imperial College researchers showed that "resveratrol did not act as an estrogen or glucocorticosteroid," each of which have patient acceptance issues.

Resveratrol from red wine has long been associated with the so-called "French Paradox," reflecting the low incidence of heart disease among the French despite their relatively high-fat diet. It is a polyphenolic compound found in the skins of such red fruits as grapes and plums, the red skin of peanuts, and even peanut butter. However, Donnelly noted there's "no evidence that COPD, asthma (especially in asthmatic smokers) or related diseases have lower incidence in France or elsewhere in the Mediterranean region."

OTC versions not useful: aerosol version needed

Moreover, Donnelly warned that their research group had "looked at the over-the-counter" versions of res
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28-Oct-2004


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