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Reduced body temperature extends lifespan in study from the Scripps Research Institute

Research Center at Scripps Research, and an author of the paper. "It works at the level of the thermoregulatory set point that is governed by intra-brain temperature and neurotransmitters. This mechanism, we believe, will be a good target for pharmacological manipulation or heating."

The idea to manipulate the temperature set-point came when Conti and Bartfai joined Scripps Research in the year 2000. Both scientists share common interests in neuroimmunology and the mechanisms of fever. It took over five years of work to conclude this study.

The researchers are now working to identify the precise mechanisms that are responsible for the beneficial effects of reduced core body temperature. They are also investigating whether their findings can be applied to research on obesity.


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Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
2-Nov-2006


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