Cambridge, MA, October 20, 2005 -- Reify Corporation announced today that the company's Visible DiscoveryTM platform is being showcased in two posters at the Sixth International Conference on Systems Biology (ICSB) at Harvard Medical School on October 19-24, 2005. The posters demonstrate the use of Visible Discovery for quantifying assay results from experiments in two very different biological systems: zebrafish heart function and subcellular chromosome dynamics. The posters will be presented on October 20 and 21 during the conference proceedings, and were produced by Reify collaborators at the Cardiovascular Research Center at Massachusetts General Hospital (MGH) and the Dana Farber Cancer Institute (DFCI).

One poster, "Machine Learning Approaches to High-Throughput In Vivo Analysis of Cardiovascular Structure and Function in Zebrafish," illustrates Reify's breakthrough capabilities for measuring dynamic cardiovascular function in living zebrafish embryos treated with drugs. Drs. Jordan Shin and Calum A. MacRae of MGH worked with Reify to validate this novel, high-throughput method for studying heart function in intact animals using conventional transmitted light microscopy. "The zebrafish represents an outstanding model system for studying a wide range of diseases, developmental pathways and genetic perturbations," said Dr. Shin. "Zebrafish are vertebrate animals that share most major organs and anatomical systems with humans and other mammals. They reproduce quickly--so that you can develop large, uniform genetic populations--and the transparent embryos develop externally so that you can visualize and record organ physiology with ordinary microscopes. Zebrafish are also an emerging model for assessing toxicities of drug candidates. Traditional quantification of cardiac function is a laborious and time-consuming process. Reify's Visible Discovery technology provides a rich solution with fast, unbiased results."

A second poster, "Tra
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Contact: Sean Walter
info@reifycorp.com
617-350-7000
Reify Corporation
20-Oct-2005

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