HOME >> BIOLOGY >> NEWS
Remote control for human growth hormone gene expression

(Philadelphia, PA) - Researchers at the University of Pennsylvania School of Medicine recently discovered a novel mechanism that works over an extensive genomic distance and controls the expression of human growth hormone (hGH) in the pituitary gland. This mechanism involves a newly discovered set of "non-coding RNAs" expressed in the vicinity of the hGH gene.

By examining the relationship between these non-coding RNAs and the hGH gene, researchers hope to understand how these remote regions impact hGH gene expression and dysfunction. Such insight may aid researchers in the development of therapeutics for growth hormone defects and lead to a greater understanding of the causes of other genetic disorders.

The human genome is comprised of both non-coding DNA and coding regions, or genes. While researchers once believed that only genes were transcribed into messenger RNA (mRNA), investigators have recently discovered that non-coding DNA is copied into mRNA as well. Unlike coding mRNAs, which are translated into functional proteins and peptides, the function of most non-coding RNAs is unclear. Although non-coding RNAs fail to produce functional proteins, researchers believe that in some cases these RNAs may control gene expression.

Using a genetically modified mouse model, Nancy E. Cooke, MD, Stephen A. Liebhaber, MD, Professors of Genetics and Medicine, and colleagues, demonstrated a critical role of two non-coding regions on the activation of the hGH gene. They described their recent findings in the August issue of Molecular Cell.

Synthesized by the pituitary gland, human growth hormone activates growth and cell reproduction. In addition to serving as a major contributor to height growth during childhood, hGH plays a role in strengthening bones and increasing muscle mass throughout life. While mutations to the hGH gene often lead to abnormal growth in children and adults, these mutations have provided researchers with key cl
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
11-Aug-2006


Page: 1 2 3

Related biology news :

1. Remote sheep population resists genetic drift
2. Remote latrine reconfirms the presence of Essene sect at Qumran
3. Remote island provides clues on population growth, environmental degradation
4. Remote imagery aids in detecting and managing plant disease
5. Remote control flies?: Fly behavior controlled by laser light
6. Circadian clock controls plant growth hormone
7. Weizmann Institute scientists discover a control mechanism for metastasis
8. Researchers find pathway that controls cell size and division
9. Penn researchers discover how microRNAs control protein synthesis
10. Biocontrol of invasive water hyacinth contributes to socioeconomic and health improvements in Africa
11. Amoebae control cheating by keeping it in the family

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2020)... , ... August 06, 2020 , ... ... industry, is pleased to announce that Eric Chen and Jessica Wong have joined ... Product Management & Strategy, respectively. , Eric Chen heads development efforts for Alucio’s ...
(Date:7/31/2020)... ... July 30, 2020 , ... Justin Zamirowski to lead upcoming ... term focus on Type 2 diabetes and associated comorbidities. , Justin brings over ... and classes. As Chief Commercial Officer, Justin will lead Better Therapeutics’ ...
(Date:7/10/2020)... ... ... Today CJ BIO announced the first in a series of Food Ingredient MasterClass ... is revolutionizing ingredient mixes, nutritional content and flavor profiles across a range of savory ... at11:00 AM (CDT) during SHIFT20, the virtual edition of the IFT Annual Meeting & ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... 29, 2020 , ... Anomet Products has introduced new custom ... use with CRM, neurostimulation, vascular, and related devices. , Anomet Medical Clad ... performance, and cost criteria; especially where solid wire is limited. Typical configurations for ...
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been ... webinar will cover the history of eSource, the reasons it did not take off ... wearables, to site source, the industry is moving towards capturing data electronically for clinical ...
(Date:7/31/2020)... SAN FRANCISCO (PRWEB) , ... ... ... fast-growing provider of cloud-based software for the life sciences industry, today announced ... and presentation platform designed specifically for Medical Science Liaisons (MSLs) and other ...
(Date:7/18/2020)... ... , ... After research model surgery and catheter implantation, the long journey of ... beginning of a successful study, while protecting and accessing the catheter or device post-surgery ... Surgery from Envigo in a live webinar on Wednesday, August ...
Breaking Biology Technology:
Cached News: