HOME >> BIOLOGY >> NEWS
Remote control for human growth hormone gene expression

ues regarding the genomic areas that appear to control expression of the hGH gene.

Previous work in the laboratories of Cooke and Liebhaber found that the hGH gene is controlled by a non-coding DNA region, or locus control region. Remarkably, this region is located more than 14,000 base pairs away from the hGH gene. At the genomic level, a 14,000 base-pair separation is equal to the size of 10 growth hormone genes lined end to end. "The effects of the locus control region on human growth hormone expression is as if you turn a key in the lock of a house at one end of your street and find that this action opens the lock and door of a house a block away," notes Liebhaber.

By carefully analyzing the 14,000 base pairs separating the hGH gene and its locus control region, co-authors Yugong Ho, PhD, an Instructor of Genetics at Penn and a Cooke/Liebhaber lab member, and Felice Elefant, PhD, Assistant Professor at Drexel University and former member of the Cooke/Liebhaber lab, found that the locus control region was copied into RNA, and discovered a gene called CD79b within this region. Remarkably this CD79b gene was also copied into RNA in the pituitary. While the CD79b gene normally codes for a protein in blood lymphocytes, researchers discovered that CD79b appears to play a very different role in the pituitary gland. Here, CD79b was actively transcribed into mRNA, but this mRNA failed to translate into a functional protein. Instead, the non-coding RNA was suspected to play a role in hGH gene regulation.

In order to determine whether the CD79b RNA in the pituitary gland served a function, Ho inserted a segment of human DNA that included hGH, the hGH locus control region, and CD79b into a group of mice. As a result, the transgenic mice expressed high levels of human growth hormone in the pituitary as well as mouse growth hormone. To test whether the transcription of the locus control region and CD79b played a significant role in hGH expressi
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
11-Aug-2006


Page: 1 2 3

Related biology news :

1. Remote sheep population resists genetic drift
2. Remote latrine reconfirms the presence of Essene sect at Qumran
3. Remote island provides clues on population growth, environmental degradation
4. Remote imagery aids in detecting and managing plant disease
5. Remote control flies?: Fly behavior controlled by laser light
6. Circadian clock controls plant growth hormone
7. Weizmann Institute scientists discover a control mechanism for metastasis
8. Researchers find pathway that controls cell size and division
9. Penn researchers discover how microRNAs control protein synthesis
10. Biocontrol of invasive water hyacinth contributes to socioeconomic and health improvements in Africa
11. Amoebae control cheating by keeping it in the family

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Remote control for human growth hormone gene expression

(Date:11/4/2014)... LAKE CITY, Nov. 5, 2014 – University of Utah ... enzymes to help jet fuel produce electricity without needing ... be used to power portable electronics, off-grid power and ... online today in the American Chemical Society journal ... electricity through a chemical reaction between a fuel and ...
(Date:11/4/2014)... PA) – Temple University School of Medicine announced ... winner, an initiative funded by the Bill & ... Professor of Obstetrics, Gynecology and Reproductive Sciences; and ... Temple University School of Medicine will pursue an ... "Maternal Blood Biomarkers to Assess Fetal Neurodevelopment.", Grand ...
(Date:11/4/2014)... A newly published research study examining only marketing ... of fast food restaurants has found that the ... disproportionately exposed to such marketing tactics. , Authored ... her colleagues, the study is the first to ... interior and exterior of fast food restaurants and ...
Breaking Biology News(10 mins):Jet-fueled electricity at room temperature 2Temple University School of Medicine receives Grand Challenges Explorations grant 2Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3
(Date:11/24/2014)... 24, 2014 2014 Deep Research ... is a professional and in-depth research report on ... information, like its definition, classification, application, and industry ... report covers the international market analysis, including China’s ... the US, Europe, Asia, China, Japan etc. regions) ...
(Date:11/24/2014)... , Nov. 24, 2014  Spherix Incorporated ... company committed to the fostering and monetization of ... v. VTech Telecommunications Ltd.,  Case No. 3:13-cv-03494-M and  ... No. 3:13-cv-03496-M, both in the United States District ... Texas . On November ...
(Date:11/23/2014)... Apiscent Labs, a privately held ... ingredients to the global pharmaceutical and flavor & ... website, Apiscent.com. , The Apiscent.com homepage welcomes visitors ... easy navigation, rotating images and content focused on ... , The company’s work in Pharmaceutical ...
(Date:11/22/2014)... (PRWEB) November 21, 2014 During his ... understood the need to surround himself with great people ... and entrepreneur, his friends often marveled at his extraordinarily ... lived his life and -- even with his death ... the Alzheimer’s disease that would ultimately take his life. ...
Breaking Biology Technology:Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 2Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 3Markman Hearing Held as Scheduled in VTech and Uniden Cases 2Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 2Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 3
Cached News: