HOME >> BIOLOGY >> NEWS
Report calls for improved monoclonal antibodies against solid tumors

A new report by leading experts in monoclonal antibody research for oncology offers a conceptual framework for future research in the design of antibody therapies against solid tumors. Writing in the January 15, 2007 issue of CANCER (http://www.interscience.wiley.com/cancer-newsroom), a peer-reviewed journal of the American Cancer Society, the researchers note that 85 percent of cancers involve solid tumors, but only 25 percent of approved antibody therapies are directed at solid tumor targets. The researchers suggest manipulation of the physical properties of a monoclonal antibody as a potentially effective way to improve antibody treatments for solid tumors.

Monoclonal antibodies ability to target a single specific protein on cancer cells, has led to their being called a magic bullet that targets only cancer cells while minimizing collateral damage to healthy tissue. That damage causes the toxicity associated with chemotherapy and radiation therapy. In the nearly 20 years since scientists were able to create monoclonal antibodies that could be safely used in humans, eight monoclonal antibodies have been approved for use in clinical treatments to trigger immune responses to cancer cells, modulate cancer cell growth, and deliver drugs to cancer cells. Of these, only three are used on solid tumors. However, solid tumors account for 85 percent of all cancers.

According to review lead author Robert A. Beckman, M.D. of the Department of Clinical Hematology and Oncology at Centocor Research & Development, Inc. in Malvern, PA and his co-authors, Louis M. Weiner, M.D. of Fox Chase Cancer Center in Philadelphia and Hugh M. Davis, Ph.D. of the Department of Clinical Pharmacology and Experimental Medicine at Centocor, a major difficulty in developing monoclonal antibody treatments for solid tumors has been their ability to penetrate the tumor. To be effective, the treatment must gain acce
'"/>

Contact: David Greenberg
dgreenbe@wiley.com
201-748-6484
John Wiley & Sons, Inc.
11-Dec-2006


Page: 1 2

Related biology news :

1. Report recommends off-site disposal of secondary waste
2. SNM initiatives supported by inclusions in NAS Report on competitiveness of US chemistry research
3. AAAS/EurekAlert! refocus on China with 2007 Fellowships for Science Reporters in Developing Regions
4. Report outlines funding to conserve half of Massachusettss land
5. Report challenges common ecological hypothesis about species abundance
6. Report highlights change in Canadas forests
7. Report: Canadas Yellowstone too small for wildlife
8. Report warns about carbon dioxide threats to marine life
9. Report focuses on the role good microbes play in future medicine
10. Herringtons annual 2006 State of the Shore Report, May 22
11. Report finds cruise industry is protecting the precious places it visits

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: