HOME >> BIOLOGY >> NEWS
Reprogrammed fibroblasts identical to embryonic stem cells

CAMBRIDGE, Mass. (June 6, 2007) -- Embryonic stem cells are unique because they can develop into virtually any kind of tissue type, an attribute called pluripotency. Somatic cell nuclear transfer (therapeutic cloning) offers the hope of one day creating customized embryonic stem cells with a patients own DNA. Here, an individuals DNA would be placed into an egg, resulting in a blastocyst that houses a supply of stem cells. But to access these cells, researchers must destroy a viable embryo.

Now, scientists at Whitehead Institute have demonstrated that embryonic stem cells can be created without eggs. By genetically manipulating mature skin cells taken from a mouse, the scientists have transformed these cells back into a pluripotent state, one that appears identical to an embryonic stem cell in every way. No eggs were used, and no embryos destroyed.

These reprogrammed cells, by all criteria that we can apply, are indistinguishable from embryonic stem cells, says Whitehead Member and MIT professor of biology Rudolf Jaenisch, senior author of the paper that will appear online June 6 in Nature.

Whats more, these reprogrammed skin cells can give rise to live mice, contributing to every kind of tissue type, and can even be transmitted via germ cells (sperm or eggs) to succeeding generations. Germline transmission is the final and definitive proof that these cells can do anything a traditionally derived embryonic stem cell can do, adds Jaenisch.

Two additional papers report similar findings. The first, by Shinya Yamanaka of Kyoto University, will be published in the same issue of Nature. The second, from Konrad Hochedlinger, formerly of the Jaenisch lab and now at Center for Regenerative Medicine at Massachusetts General Hospital and Harvard Stem Cell Institute, will appear in the inaugural issue of the journal Cell Stem Cells. Additionally, another paper in Nature from Kevin Eggan, also of the Harvard Stem Cell Institute an
'"/>

Contact: David Cameron
newsroom@wi.mit.edu
617-324-0460
Whitehead Institute for Biomedical Research
6-Jun-2007


Page: 1 2 3 4

Related biology news :

1. A twist of fate -- Reprogrammed fibroblasts resemble embryonic stem cells
2. First case of successful ovarian tissue transplantation between two, nonidentical sisters
3. How can identical twins be genetically different?
4. Cloned stem cells prove identical to fertilized stem cells
5. UCLA scientists produce functioning neurons from human embryonic stem cells
6. Not all embryonic stem cell lines are created equal
7. Discredited Korean embryonic stem cells true origins revealed
8. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
9. Study: Donated embryos could result in more than 2,000 new embryonic stem cell lines
10. UCLA researchers reprogram normal tissue cells into embryonic stem cells
11. Left-right wiring determined by neural communication in the embryonic worm

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Reprogrammed fibroblasts identical embryonic stem cells

(Date:7/28/2014)... of Medicine have pinpointed a mechanism in part of the ... blood, linking it to both type 1 and type 2 ... of Proceedings of the National Academies of Sciences . ... located in a part of the hypothalamus known as the ... that control glucose levels in the blood," said lead author ...
(Date:7/28/2014)... the top 10 U.S. cities that have seen an ... as frequent road closures, overwhelmed storm drains and compromised ... NOAA technical report. , This nuisance flooding, caused by ... coasts, between 300 and 925 percent since the 1960s. ... Frequency Changes around the United States, also finds Annapolis ...
(Date:7/28/2014)... has identified areas of the Earth that are high ... , Europe is particularly vulnerable, as it has the ... cent, of any continent in ,refugia, areas of ... conditions remain relatively constant during times of great environmental ... mostly in Scandinavia and Scotland. , The biggest ...
Breaking Biology News(10 mins):Glucose 'control switch' in the brain key to both types of diabetes 2NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 2NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 3Study finds Europe's habitat and wildlife is vulnerable to climate change 2
(Date:7/29/2014)... 2014 A new report by ... applications and geography) - Size, Share, Global Trends, Company ... Forecast, 2013 - 2020", suggests that the global surgical ... 2020 registering a CAGR of 11.1% from 2014 to ... the electro surgical devices in operative procedures by providing ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 July ... vaccine pioneer in the biotechnology industry, announced that ... Coast Securities, Inc. to explore financing opportunities that ... technology, a breakthrough vaccine platform with the potential ... The company exclusively licensed the well-established LAMP platform ...
(Date:7/29/2014)... 2014 DisasterTalk is a texting app which ... phone masts or other transmitters are down. The app can ... without the need for any Wi-Fi, and can also use ... new app has launched as a housing report ... high risk of being affected by natural disasters. With the ...
(Date:7/29/2014)... The first product launch from start-up Hurley ... robotics. What sets Droidles completely apart from other stand ... them to communicate, share code with each other and ... “The invention is the system,” said Hurley Research founder ... of their own, both physically and on the internet." ...
Breaking Biology Technology:Global Surgical Equipment Market is expected to reach $12.1 billion by 2020 - Allied Market Research 2Global Surgical Equipment Market is expected to reach $12.1 billion by 2020 - Allied Market Research 3Immunomic Therapeutics Engages Newport Coast Securities, Inc. 2Immunomic Therapeutics Engages Newport Coast Securities, Inc. 3DisasterTalk App Could Save Lives as Report Reveals 8% of US Homes at Very High Risk of Natural Disaster 2Droidles, the Social Network of Robots and Open Source Platform for the Internet of Things, Launches for Crowd Funding on IndieGoGo.com 2
Cached News: