HOME >> BIOLOGY >> NEWS
Reprogrammed fibroblasts identical to embryonic stem cells

CAMBRIDGE, Mass. (June 6, 2007) -- Embryonic stem cells are unique because they can develop into virtually any kind of tissue type, an attribute called pluripotency. Somatic cell nuclear transfer (therapeutic cloning) offers the hope of one day creating customized embryonic stem cells with a patients own DNA. Here, an individuals DNA would be placed into an egg, resulting in a blastocyst that houses a supply of stem cells. But to access these cells, researchers must destroy a viable embryo.

Now, scientists at Whitehead Institute have demonstrated that embryonic stem cells can be created without eggs. By genetically manipulating mature skin cells taken from a mouse, the scientists have transformed these cells back into a pluripotent state, one that appears identical to an embryonic stem cell in every way. No eggs were used, and no embryos destroyed.

These reprogrammed cells, by all criteria that we can apply, are indistinguishable from embryonic stem cells, says Whitehead Member and MIT professor of biology Rudolf Jaenisch, senior author of the paper that will appear online June 6 in Nature.

Whats more, these reprogrammed skin cells can give rise to live mice, contributing to every kind of tissue type, and can even be transmitted via germ cells (sperm or eggs) to succeeding generations. Germline transmission is the final and definitive proof that these cells can do anything a traditionally derived embryonic stem cell can do, adds Jaenisch.

Two additional papers report similar findings. The first, by Shinya Yamanaka of Kyoto University, will be published in the same issue of Nature. The second, from Konrad Hochedlinger, formerly of the Jaenisch lab and now at Center for Regenerative Medicine at Massachusetts General Hospital and Harvard Stem Cell Institute, will appear in the inaugural issue of the journal Cell Stem Cells. Additionally, another paper in Nature from Kevin Eggan, also of the Harvard Stem Cell Institute an
'"/>

Contact: David Cameron
newsroom@wi.mit.edu
617-324-0460
Whitehead Institute for Biomedical Research
6-Jun-2007


Page: 1 2 3 4

Related biology news :

1. A twist of fate -- Reprogrammed fibroblasts resemble embryonic stem cells
2. First case of successful ovarian tissue transplantation between two, nonidentical sisters
3. How can identical twins be genetically different?
4. Cloned stem cells prove identical to fertilized stem cells
5. UCLA scientists produce functioning neurons from human embryonic stem cells
6. Not all embryonic stem cell lines are created equal
7. Discredited Korean embryonic stem cells true origins revealed
8. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
9. Study: Donated embryos could result in more than 2,000 new embryonic stem cell lines
10. UCLA researchers reprogram normal tissue cells into embryonic stem cells
11. Left-right wiring determined by neural communication in the embryonic worm

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... , April 5, 2017  The Allen Institute ... Allen Cell Explorer: a one-of-a-kind portal and dynamic digital ... 3D imaging data, the first application of deep learning ... human stem cell lines and a growing suite of ... platform for these and future publicly available resources created ...
(Date:4/5/2017)... 4, 2017 KEY FINDINGS The ... at a CAGR of 25.76% during the forecast period ... primary factor for the growth of the stem cell ... MARKET INSIGHTS The global stem cell market ... and geography. The stem cell market of the product ...
(Date:4/3/2017)... , April 3, 2017  Data captured ... engineering platform, detected a statistically significant association ... prior to treatment and objective response of ... potential to predict whether cancer patients will ... treatment, as well as to improve both pre-infusion ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... 2017 , ... RURO, Inc., a leading LIMS, RFID, and ... update to the Limfinity® framework. , LimitLIS® and other RURO solutions based on ... customers among labs and other businesses. Limfinity® 6.5 adds new features and improvements ...
(Date:6/20/2017)... ... June 20, 2017 , ... CTNext ... of directors has formed a Higher Education Entrepreneurship Advisory Committee to implement the ... presidents and other high-ranking representatives from 35 higher education institutions across the state ...
(Date:6/20/2017)... ... 20, 2017 , ... HorizonScan is providing food and ingredient ... likely threat to their products at the annual IFT conference in Las Vegas, ... expo attracts over 20,000 attendees representing food science professionals from over 90 countries ...
(Date:6/20/2017)... ... 2017 , ... National executive search firm, Slone Partners, announces ... and biomarker expertise, as VP of Scientific Affairs at Cambridge Biomedical. , ... development and sample testing services. The organization acts as a leading provider of ...
Breaking Biology Technology:
Cached News: