HOME >> BIOLOGY >> NEWS
Rescuing injured hearts by enhancing regeneration

Using a two-drug approach, researchers at Children's Hospital Boston have demonstrated that it may be possible to rescue heart function after a heart attack and protect the heart from scarring. Working with rats, they combined an agent that overcomes a natural inhibitor of cell division with a naturally occurring growth factor that encourages blood vessel growth (angiogenesis). Together, these two agents enabled heart-muscle cells to multiply and the heart to regain its function after a simulated myocardial infarction. The study will appear in the October 17 issue of the Proceedings of the National Academy of Sciences (posted online during the week of October 9).

Normally, after a heart attack, the damaged heart muscle cannot grow back and is instead replaced by scar tissue. Excessive scarring can impair the heart's pumping capacity and can lead to life-threatening arrhythmias. Heart-muscle cells (cardiomyocytes) normally cannot replicate in mammals, a major obstacle to regeneration. However, in a paper last year, Felix Engel, PhD, and Mark Keating, MD, in the Department of Cardiology at Children's Hospital Boston, showed that they could coax cardiomyocytes to multiply in a petri dish by inhibiting an enzyme known as p38 MAP kinase, which normally suppresses cardiomyocyte replication. [See: www.childrenshospital.org/newsroom/Site1339/mainpageS1339P1sublevel139.html]

Engel and Keating (Keating is now at the Novartis Institute for BioMedical Research) now build on this finding. They studied 120 rats, some with simulated heart attacks. After the injury, the animals were randomly assigned to receive injections with a p38 MAP kinase inhibitor alone, the angiogenesis stimulator FGF1 alone, both agents together, or saline (placebo) for four weeks. Three months later, rats that had received both FGF1 and the p38 MAP kinase inhibitor had markedly improved h
'"/>

Contact: Anna Gonski
anna.gonski@childrens.harvard.edu
617-355-6420
Children's Hospital Boston
9-Oct-2006


Page: 1 2 3

Related biology news :

1. Radiation therapy combined with microsurgery shows promise for curing injured spinal cord
2. Scientists identify key to integrating transplanted nerve cells into injured tissue
3. Interdisciplinary team develops guidelines for treating severely injured patients
4. Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves
5. Weizmann Institute scientists discover how substitutions are made for injured genes
6. Cardio exercise benefits in male vs. female hearts
7. Coarse particulate matter in air may harm hearts of asthma sufferers, UNC study finds
8. Adult stem cells to repair hearts damaged by severe coronary artery disease investigated
9. Newts which regrow their hearts
10. UT Southwestern researchers find gene mutation that leads to broken hearts
11. Adult stem cell research at UB targets damaged hearts

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/16/2019)... ... April 16, 2019 , ... The ... signature events: The 2019 ISPE Biopharmaceutical Manufacturing Conference , on 18–20 June ... place in one of the most influential bio hubs, Boston, Massachusetts USA, these ...
(Date:4/9/2019)... ... ... The McLeod Center for Cancer Treatment and Research has been ... conducted by an independent, third-party panel of experts in radiation oncology, patient safety and ... McLeod is the only such cancer center in South Carolina. The hospital also represents ...
(Date:4/4/2019)... ... April 02, 2019 , ... ... company, will present results demonstrating that RNA genetic testing (RGT), as a supplement ... study, awarded as a Top Rated poster, is one of 13 presentations at ...
Breaking Biology News(10 mins):
(Date:3/29/2019)... ... March 28, 2019 , ... Specific ... CARB-X has proceeded with a second stage of funding for Specific’s Reveal™ rapid ... is on top of the $1.7 million already awarded by CARB-X. The additional ...
(Date:3/23/2019)... Pa. (PRWEB) , ... March 22, 2019 , ... ... of its LenS3 Multi-Angle Light Scattering (MALS) detector , offering a revolutionary ... of synthetic polymers, polysaccharides, proteins, and biopolymers. A novel optical design, a unique ...
(Date:3/19/2019)... ... ... free webinar will review strategies for data management in modular and adaptive clinical ... times by up to 30 percent, reducing cost while increasing quality, achieving clinical site set-up ... to migrate data – reducing risk and impact on trial success, trial teams, and trial ...
(Date:3/14/2019)... ... March 14, 2019 , ... EyeCRO LLC has been ... EyeCRO joins the Department of Veterans Affairs, the Oklahoma Medical Research Foundation, Oklahoma ... institution in Oklahoma to receive this prestigious endorsement. The award letter from ...
Breaking Biology Technology:
Cached News: