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Research aims to identify markers for menopausal women at risk for deadly blood clot

t for thrombotic risk in one woman over another.

The study design takes into account the researchers belief that three forces an injury, a platelet effect at the injury, and the inflammation that affects the platelet and the vessel wall are involved in the development of thrombotic risk.

The study builds on the teams earlier findings in an animal model. They are applying the earlier results to a human population for the first time using blood taken from the women enrolled in the KEEPS trial. Depending upon the results from this group, a larger trial of 720 samples will be examined.

Depending on the results of this study, the researchers may examine the relationship of platelet activity, inflammation, and cardiovascular risk (CV) in men. It is well known that men have a higher risk factor for cardiovascular disease (CVD) than do females, and arterial clots, rather than venous clots, are a greater concern in the presence of CVD. Since men carry the female hormone estrogen as well as the male hormone testosterone, some of the findings from the female KEEPS study may shed light on these mechanisms involving men.

Conclusion

According to Dr. Miller, This type of research brings us closer to defining risk profiles for a specific health issue. Our hope is that it can lead to tools that will allow doctors to provide hormonal therapy for their female patients that is commensurate with a womans risk for venous thrombosis.


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Contact: Donna Krupa
dkrupa@the-aps.org
301-634-7253
American Physiological Society
8-Aug-2007


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