HOME >> BIOLOGY >> NEWS
Research focusing on why estrogenic hormones produce differing results

CHAMPAIGN, Ill. -- New research is shedding light on why estrogenic hormones produce unintended results in women, giving hope to the idea that new drugs might reach their targets and work more effectively. Ultimately it could mean that postmenopausal women would know that hormone-replacement therapy would have only its intended result.

"It's very difficult right now for women to make a choice about taking estrogen or other estrogen-like compounds, and, I think, it's equally difficult for physicians to try to tell women what they should do," said Ann M. Nardulli, a professor in the department of molecular and integrative physiology at the University of Illinois at Urbana-Champaign.

Nardulli was the principal investigator of a study published in the Jan. 7 issue of the Journal of Biological Chemistry. In the study, Nardulli, doctoral student Jennifer R. Schultz and postgraduate researcher Larry N. Petz added fuel to the argument that the long-held model for how an estrogen receptor binds to DNA and, in turn, regulates gene transcription is need of retooling.

Nardulli's team has found four discrete regions of the human progesterone receptor gene that confer hormone responsiveness. In the study, the activities of estradiol, tamoxifen, raloxifene and the soy phytoestrogens genestein and daidzein were examined and compared in uterine, mammary and bone cell lines. The researchers found vast differences based on the four regions.

"The model has always been that the estrogen receptor binds to DNA to activate transcription, but now we show that that's not always the case," Nardulli said. "Binding doesn't occur equally well in different kinds of tissue, and it requires a broader vision on how transcription changes the functions in cells."

The value of hormone-replacement therapy has come under scrutiny because of links to various cancers. It's also been discovered that women taking tamoxifen to protect against a relapse of breast canc
'"/>

Contact: Jim Barlow, Life Sciences Editor
jebarlow@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
11-Feb-2005


Page: 1 2 3

Related biology news :

1. Gilbert Foundation and American Fed for Aging Research award grants on Alzheimers disease
2. Research shows skeleton to be endocrine organ
3. Research aims to identify markers for menopausal women at risk for deadly blood clot
4. Research team enlightens the reasons for severe blindness
5. Research teams uncover risk genes for multiple sclerosis
6. Research shows NPD1 protects a key component of vision
7. Researchers find pathway that controls cell size and division
8. Researchers watch antibiotics, bacteria meet at atomic level
9. Researchers discover gene responsible for Restless Legs Syndrome
10. Research study describes the role part of the brain plays in memory
11. NY Stem Cell Foundations 2nd Annual Translational Stem Cell Research Conference

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... July 09, 2020 , ... Today CJ BIO announced ... will share insight on the “fifth taste” phenomenon that is revolutionizing ingredient mixes, nutritional ... Advantage will be live on Monday, July 13, 2020 at11:00 AM (CDT) during SHIFT20, ...
(Date:7/1/2020)... (PRWEB) , ... July 01, 2020 , ... ... building awareness and solutions for glioblastoma—the most common and aggressive adult brain cancer—announced ... Haile, JD, PhD. Senior Fellows are charged with supporting the organization’s initiatives and ...
(Date:6/23/2020)... ... June 23, 2020 , ... First ... Renovagen Ltd, a UK supplier and manufacturer of innovative portable renewable energy equipment, ... in the fight against the COVID-19 pandemic in Zambia. , One of Renovagen’s ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra , ... sciences and food industries, is pleased to announce that Charles Galea has joined ... Development. , Charles is an accomplished and results-driven sales executive with over 10 ...
(Date:7/10/2020)... HONG KONG (PRWEB) , ... July 09, 2020 ... ... chemical compound called 1-phenyl-2-thiourea (PTU) is commonly used to suppress pigment formation in ... years, the PolyU research team led by Dr MA has been using the ...
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT World has ... Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts General Hospital, Mission: Cure, and ... elite awards program, highlighting outstanding examples of how technology innovations and strategic initiatives ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... today announced that the launch of a new clinical diagnostics immuno-oncology ... the tumor microenvironment (TME). , “Flagship’s TissueInsight is a service that aids ...
Breaking Biology Technology:
Cached News: