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Research focusing on why estrogenic hormones produce differing results

exactly the tissues you want to affect without affecting any others."

Such work is already beginning to take shape in other labs at Illinois.

A team led by John A. Katzenellenbogen, a professor of chemistry, and his wife, Benita S. Katzenellenbogen, a professor of molecular and integrative physiology and of cell and structural biology in the College of Medicine at Urbana-Champaign, recently have produced a series of synthesized, non-steroidal estrogenic compounds that seek out and bind with ER-beta very selectively.

In a paper appearing online in advance of regular publication in the Journal of Medicinal Chemistry, published by the American Chemical Society, the Katzenellenbogens report that their compounds work on ER-beta nearly identically to estradiol, but they have almost no effect on the other estrogen receptor, ER-alpha.

"These compounds might prove useful as selective pharmacological probes to study the biological actions of estrogens mediated through ER-beta, and they might lead to the development of useful pharmaceuticals," they wrote in the journal paper.


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Contact: Jim Barlow, Life Sciences Editor
jebarlow@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
11-Feb-2005


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