HOME >> BIOLOGY >> NEWS
Research group gets $7 million to pursue new antibiotic agents

in the microbial metabolism of phosphate compounds.

About 70 percent of the antibiotics currently in use come from bacteria. Metcalfs fascination with the ongoing "biological warfare between bacteria" led him to explore the antimicrobial potential of phosphonates. While phosphonates have found uses in medicine to treat malaria or hypertension this area of research is fairly new, he said.

"No one has even made a dedicated search for phosphonates in nature," he said.

Metcalf and his collaborators have analyzed the biological activity of some known phosphonates,such as the herbicide phosphinothricin. The van der Donk and Zhao groups have investigated the clinically used phosphonate, fosfomycin.

Kelleher, a biological mass spectroscopist, has constructed several new, high-resolution Fourier Transform mass spectrometers, which will help the researchers isolate previously unknown microbial products that contain the phosphonate group.

Nair is an X-ray crystallographer with expertise in elucidating the three-dimensional structure of protein and DNA complexes.

The research team has four goals: the discovery and genetic characterization of phosphonate biosynthetic pathways; the biochemical reconstruction of those pathways that have antibiotic or other therapeutic potential; the bioengineering of medically useful phosphonates and their biosynthetic enzymes for economical production; and the use of the latest mass spectrometric technology to discover and engineer phosphonates and enzymes that contribute to phosphonate metabolism.

"Our role is the discovery of antibiotics for which there is a critical need and the development of ways to produce these antibiotics economically," Metcalf said.


'"/>

Contact: Diana Yates
diya@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
25-Apr-2007


Page: 1 2

Related biology news :

1. Gilbert Foundation and American Fed for Aging Research award grants on Alzheimers disease
2. Research shows skeleton to be endocrine organ
3. Research aims to identify markers for menopausal women at risk for deadly blood clot
4. Research team enlightens the reasons for severe blindness
5. Research teams uncover risk genes for multiple sclerosis
6. Research shows NPD1 protects a key component of vision
7. Researchers find pathway that controls cell size and division
8. Researchers watch antibiotics, bacteria meet at atomic level
9. Researchers discover gene responsible for Restless Legs Syndrome
10. Research study describes the role part of the brain plays in memory
11. NY Stem Cell Foundations 2nd Annual Translational Stem Cell Research Conference

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/31/2016)... -- Genomics firm Nabsys has completed a financial  restructuring under ... M.D., who returned to the company in October 2015. ... including Chief Technology Officer, John Oliver , Ph.D., ... Vice President of Software and Informatics, Michael Kaiser ... Bready served as CEO of Nabsys from 2005-2014 and ...
(Date:3/22/2016)... March 22, 2016 ... Sensors Market for Consumer Industry by Type (Image, ... Application (Communication & IT, Entertainment, Home Appliances, ... Forecast to 2022", published by MarketsandMarkets, the ... to reach USD 26.76 Billion by 2022, ...
(Date:3/18/2016)... , March 18, 2016 --> ... of Biometrics, ICT, Manned & Unmanned Vehicles, Physical infrastructure and ... security companies in the border security market and the continuing ... and Europe has led visiongain to ... improved success. --> defence & security companies ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... Epic Sciences unveiled a liquid biopsy ... PARP inhibitors by targeting homologous recombination deficiency (HRD) ... test has already been incorporated into numerous clinical ... Over 230 clinical trials are investigating ... PARP, ATM, ATR, DNA-PK and WEE-1. Drugs targeting ...
(Date:6/23/2016)... Wausau, WI (PRWEB) , ... June 23, 2016 ... ... probiotic supplements, is pleased to announce the launch of their brand, UP4™ Probiotics, ... supplements for over 35 years, is proud to add Target to its list ...
(Date:6/23/2016)... 2016 Houston Methodist Willowbrook Hospital has ... Association to serve as their official health care ... Willowbrook will provide sponsorship support, athletic training services, ... coaches, volunteers, athletes and families. "We ... Association and to bring Houston Methodist quality services ...
(Date:6/23/2016)... FRANCISCO , June 23, 2016   EpiBiome ... has secured $1 million in debt financing from Silicon ... ramp up automation and to advance its drug development ... its new facility. "SVB has been an ... beyond the services a traditional bank would provide," said ...
Breaking Biology Technology:
Cached News: