HOME >> BIOLOGY >> NEWS
Research group gets $7 million to pursue new antibiotic agents

in the microbial metabolism of phosphate compounds.

About 70 percent of the antibiotics currently in use come from bacteria. Metcalfs fascination with the ongoing "biological warfare between bacteria" led him to explore the antimicrobial potential of phosphonates. While phosphonates have found uses in medicine to treat malaria or hypertension this area of research is fairly new, he said.

"No one has even made a dedicated search for phosphonates in nature," he said.

Metcalf and his collaborators have analyzed the biological activity of some known phosphonates,such as the herbicide phosphinothricin. The van der Donk and Zhao groups have investigated the clinically used phosphonate, fosfomycin.

Kelleher, a biological mass spectroscopist, has constructed several new, high-resolution Fourier Transform mass spectrometers, which will help the researchers isolate previously unknown microbial products that contain the phosphonate group.

Nair is an X-ray crystallographer with expertise in elucidating the three-dimensional structure of protein and DNA complexes.

The research team has four goals: the discovery and genetic characterization of phosphonate biosynthetic pathways; the biochemical reconstruction of those pathways that have antibiotic or other therapeutic potential; the bioengineering of medically useful phosphonates and their biosynthetic enzymes for economical production; and the use of the latest mass spectrometric technology to discover and engineer phosphonates and enzymes that contribute to phosphonate metabolism.

"Our role is the discovery of antibiotics for which there is a critical need and the development of ways to produce these antibiotics economically," Metcalf said.


'"/>

Contact: Diana Yates
diya@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
25-Apr-2007


Page: 1 2

Related biology news :

1. Gilbert Foundation and American Fed for Aging Research award grants on Alzheimers disease
2. Research shows skeleton to be endocrine organ
3. Research aims to identify markers for menopausal women at risk for deadly blood clot
4. Research team enlightens the reasons for severe blindness
5. Research teams uncover risk genes for multiple sclerosis
6. Research shows NPD1 protects a key component of vision
7. Researchers find pathway that controls cell size and division
8. Researchers watch antibiotics, bacteria meet at atomic level
9. Researchers discover gene responsible for Restless Legs Syndrome
10. Research study describes the role part of the brain plays in memory
11. NY Stem Cell Foundations 2nd Annual Translational Stem Cell Research Conference

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2016)... March 23, 2016 ... Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender Anbieter ... Unternehmen mit SpeechPro zusammenarbeitet, um erstmals dessen ... wird die Möglichkeit angeboten, im Rahmen mobiler ...
(Date:3/22/2016)... OTTAWA, Ontario , PROVO ... 2016 Newborn Screening Ontario (NSO), which operates ... for molecular testing, and Tute Genomics and ... process management technology respectively, today announced the launch of ... new next-generation sequencing (NGS) testing panel. ...
(Date:3/18/2016)... 2016 --> --> ... Manned & Unmanned Vehicles, Physical infrastructure and Perimeter Surveillance & ... the border security market and the continuing migration crisis in ... Europe has led visiongain to publish this unique ... --> defence & security companies in the border ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... UAS LifeSciences, ... launch of their brand, UP4™ Probiotics, into Target stores nationwide. The company, which ... to add Target to its list of well-respected retailers. This list includes such ...
(Date:6/23/2016)... Houston Methodist Willowbrook Hospital has signed ... to serve as their official health care provider. ... will provide sponsorship support, athletic training services, and ... volunteers, athletes and families. "We are ... and to bring Houston Methodist quality services and ...
(Date:6/23/2016)... --  EpiBiome , a precision microbiome engineering company, today ... from Silicon Valley Bank (SVB). The financing will allow ... drug development efforts, as well as purchase additional lab ... been an incredible strategic partner to us – one ... provide," said Dr. Aeron Tynes Hammack , EpiBiome,s ...
(Date:6/23/2016)... June 23, 2016 Apellis Pharmaceuticals, Inc. ... clinical trials of its complement C3 inhibitor, APL-2. ... multiple ascending dose studies designed to assess the ... subcutaneous injection in healthy adult volunteers. ... as a single dose (ranging from 45 to ...
Breaking Biology Technology:
Cached News: