HOME >> BIOLOGY >> NEWS
Research group gets $7 million to pursue new antibiotic agents

in the microbial metabolism of phosphate compounds.

About 70 percent of the antibiotics currently in use come from bacteria. Metcalfs fascination with the ongoing "biological warfare between bacteria" led him to explore the antimicrobial potential of phosphonates. While phosphonates have found uses in medicine to treat malaria or hypertension this area of research is fairly new, he said.

"No one has even made a dedicated search for phosphonates in nature," he said.

Metcalf and his collaborators have analyzed the biological activity of some known phosphonates,such as the herbicide phosphinothricin. The van der Donk and Zhao groups have investigated the clinically used phosphonate, fosfomycin.

Kelleher, a biological mass spectroscopist, has constructed several new, high-resolution Fourier Transform mass spectrometers, which will help the researchers isolate previously unknown microbial products that contain the phosphonate group.

Nair is an X-ray crystallographer with expertise in elucidating the three-dimensional structure of protein and DNA complexes.

The research team has four goals: the discovery and genetic characterization of phosphonate biosynthetic pathways; the biochemical reconstruction of those pathways that have antibiotic or other therapeutic potential; the bioengineering of medically useful phosphonates and their biosynthetic enzymes for economical production; and the use of the latest mass spectrometric technology to discover and engineer phosphonates and enzymes that contribute to phosphonate metabolism.

"Our role is the discovery of antibiotics for which there is a critical need and the development of ways to produce these antibiotics economically," Metcalf said.


'"/>

Contact: Diana Yates
diya@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
25-Apr-2007


Page: 1 2

Related biology news :

1. Gilbert Foundation and American Fed for Aging Research award grants on Alzheimers disease
2. Research shows skeleton to be endocrine organ
3. Research aims to identify markers for menopausal women at risk for deadly blood clot
4. Research team enlightens the reasons for severe blindness
5. Research teams uncover risk genes for multiple sclerosis
6. Research shows NPD1 protects a key component of vision
7. Researchers find pathway that controls cell size and division
8. Researchers watch antibiotics, bacteria meet at atomic level
9. Researchers discover gene responsible for Restless Legs Syndrome
10. Research study describes the role part of the brain plays in memory
11. NY Stem Cell Foundations 2nd Annual Translational Stem Cell Research Conference

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Research group gets million pursue new antibiotic agents

(Date:11/6/2014)... Insilico Medicine, Inc, a Baltimore-based bioinformatics company focused ... announced a research collaboration with the international leader ... (OTC: CSBR). , "There are many companies utilizing ... Oncology,s TumorGraft technology is unique in a way ... generating vast amounts of valuable data. Our bioinformatic ...
(Date:11/5/2014)... Janeiro, Brazil -Individuals show great diversity in their ability ... and females greatly differ in their perceptual evaluation of ... smell tests. , Sex differences in olfactory ... and may be connected to one,s perception of smell, ... Thus, women,s olfactory superiority has been suggested to be ...
(Date:11/4/2014)... Temple University School of Medicine announced today that ... initiative funded by the Bill & Melinda Gates ... Obstetrics, Gynecology and Reproductive Sciences; and Vice Chair ... School of Medicine will pursue an innovative global ... Biomarkers to Assess Fetal Neurodevelopment.", Grand Challenges Explorations ...
Breaking Biology News(10 mins):Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2The female nose always knows: Do women have more olfactory neurons? 2Temple University School of Medicine receives Grand Challenges Explorations grant 2
(Date:11/26/2014)... 26, 2014 The ETC (Emerging ... technology innovation centers, announced today that applications for ... December 1st. “Do you have a big idea?,” ... want to know about it. AccelerateBaltimore helps you ... product in just 13 weeks.” Interested game ...
(Date:11/26/2014)... Whitehouse Laboratories is pleased to announce ... (New Jersey) Chamber of Commerce as a member. ... in the North Jersey area, offers Whitehouse Laboratories ... clients in the pharmaceutical and biotechnology areas that ... enables Whitehouse Laboratories a higher level of visibility ...
(Date:11/26/2014)... Sunnyvale, CA (PRWEB) November 25, 2014 ... joins forces with RPM Alliance , provider ... and pharmaceutical companies. With the latest addition to its ... only free validated EDC system to India. , ... as a robust and customizable EDC platform which is ...
(Date:11/26/2014)... 2014 The Pittcon marketing department is ... and exposition mobile app, Pittcon 2015 ... the App Store for iOS and Android devices and ... before, during and after the event. It acts as ... companies, technical sessions, Conferee Networking sessions and short courses. ...
Breaking Biology Technology:AccelerateBaltimore Applications to Close in 6 Days 2AccelerateBaltimore Applications to Close in 6 Days 3Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 3RPM Alliance Joins Clinovo’s CRO Partnership Program, Further Strengthening Its Presence in Southern California and India 2Pittcon Releases 2015 Mobile App 2
Cached News: