HOME >> BIOLOGY >> NEWS
Research shows NPD1 protects a key component of vision

Two papers to be published in the Early Edition online of the Proceedings of the National Academy of Sciences (PNAS) the week of July 30-August 3, 2007 report findings that demonstrate that neuroprotectin D1 (NPD1) protects against damage to retinal pigment epithelial (RPE) cells and identifies an important trigger for its production and novel molecular mechanisms that support vision. The research was conducted at LSU Health Sciences Center New Orleans and the papers are entitled Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling and Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis. RPE cells are responsible for the renewal of the tips of photoreceptor cells (rods and cones) crucial to vision.

Neuroprotectin D1 is a messenger (mediator) discovered by Nicolas Bazan, MD, PhD, Boyd Professor, Ernest C. and Yvette C. Villere Professor of Ophthalmology, and Director of the Neuroscience Center of Excellence at LSU Health Sciences Center New Orleans, and his colleagues that represents one of the most powerful endogenous (made by the body) neuroprotective mediators known. Its precursor is DHA (docosahexaenoic acid), an essential fatty acid (must be provided by the diet) of the omega-3 fatty acid family enriched in RPE cells in the retina and brain. DHA is a target of oxidative stress in pathological conditions and Dr. Bazans research recently showed that RPE cells create NPD1 in response to oxidative stress.

The LSUHSC scientists discovered that neurotrophins (small proteins critical in cell survival and death) trigger NPD1 synthesis. They demonstrate that the endogenous toxic component (A2E) that accumulates in the retina during aging and in retinal degenerations, including those due to gene mutations, can be counteracted by NPD1.

The LSUHSC research team conducted studies on the formation and action of NPD1 on a human tra
'"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-452-9166
Louisiana State University Health Science Center
30-Jul-2007


Page: 1 2

Related biology news :

1. Gilbert Foundation and American Fed for Aging Research award grants on Alzheimers disease
2. Research shows skeleton to be endocrine organ
3. Research aims to identify markers for menopausal women at risk for deadly blood clot
4. Research team enlightens the reasons for severe blindness
5. Research teams uncover risk genes for multiple sclerosis
6. Researchers find pathway that controls cell size and division
7. Researchers watch antibiotics, bacteria meet at atomic level
8. Researchers discover gene responsible for Restless Legs Syndrome
9. Research study describes the role part of the brain plays in memory
10. NY Stem Cell Foundations 2nd Annual Translational Stem Cell Research Conference
11. Researchers witness natural selection at work in dramatic comeback of male butterflies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/7/2018)... , ... November 07, 2018 , ... ... Catherine Lozupone, PhD, faculty of the Computational Biosciences Program within the Department of ... of leading scientists and doctors from around the world, Dr. Lozupone will bring ...
(Date:11/7/2018)... ... November 07, 2018 , ... ... firm serving the life science industry. The event was attended by 150 industry ... advance biological research and drug discovery. The winners were determined by responses to ...
(Date:11/3/2018)... ... November 01, 2018 , ... Emerging Trends in Medical ... Opportunities, **Presented by FDAnews**, Dec. 6, 2018 – Kleinfeld, Kaplan & Becker, LLP ... for Emerging Trends in Medical Device Regulation and Quality ends on Thursday, Nov. ...
Breaking Biology News(10 mins):
(Date:10/18/2018)... ... October 18, 2018 , ... With rapid technological advances in the fertility ... Previously reserved for women facing a cancer diagnosis requiring chemotherapy or removal of an ... options. Simply put, they do not want to get pregnant now but may ...
(Date:10/17/2018)... ... October 17, 2018 , ... Catalent Pharma Solutions, the ... and consumer health products, today announced that Cornell Stamoran, Ph.D., Vice President of ... annual Partnership Opportunities in Drug Delivery (PODD) meeting at the Westin Copley Place, ...
(Date:10/16/2018)... (PRWEB) , ... October 16, 2018 , ... ... Dr. Isabel Moreno-Indias, PhD, Senior Researcher at the Biomedical Research Institute of ... the Physiopathology Network of Obesity and Nutrition, to its Scientific Advisory Board. Joining ...
(Date:10/16/2018)... , ... October 15, 2018 , ... ... tissues through the visualization of histopathology slides by eye wherein key features are ... standard for diagnosis and research, it is highly limited in that it is ...
Breaking Biology Technology:
Cached News: