HOME >> BIOLOGY >> NEWS
Research shows how ultrasound can deliver therapeutic molecules into living cells

Researchers have shown how ultrasound energy can briefly "open a door" in the protective outer membranes of living cells to allow entry of drugs and other therapeutic molecules and how the cells themselves can then quickly close the door. Understanding this mechanism could advance the use of ultrasound for delivering gene therapies, targeting chemotherapy and administering large-molecule drugs that cannot readily move through cell membranes.

Using five different microscopy techniques, the researchers showed that the violent collapse of bubbles an effect caused by the ultrasound creates enough force to open holes in the membranes of cells suspended in a liquid medium. The holes, which are closed by the cells in a matter of minutes, allow entry of therapeutic molecules as large as 50 nanometers in diameter larger than most proteins and similar in size to the DNA used for gene therapy.

"The holes are made by mechanical interaction with the collapsing bubbles," said Mark Prausnitz, a professor in the School of Chemical and Biomolecular Engineering at the Georgia Institute of Technology. "The bubbles oscillate in the ultrasound field and collapse, causing a shock wave to be released. Fluid movement associated with the resulting shock wave opens holes in the cell membranes, which allow molecules from the outside to enter. The cells then respond to the creation of the holes by mobilizing intracellular vesicles to patch the holes within minutes."

Ultrasound is the same type of energy already widely used for diagnostic imaging. Drug delivery employs higher power levels and different frequencies, and bubbles may be introduced to enhance the effect.

Ultrasound drug delivery could be particularly attractive for gene therapy, which has successfully used viruses to insert genetic material into cells but with side effects. It could also be used for more targeted delivery of chemotherapy agents.

"One of
'"/>

Contact: John Toon
jtoon@gatech.edu
404-894-6986
Georgia Institute of Technology Research News
5-Sep-2006


Page: 1 2 3

Related biology news :

1. Gilbert Foundation and American Fed for Aging Research award grants on Alzheimers disease
2. Research shows skeleton to be endocrine organ
3. Research aims to identify markers for menopausal women at risk for deadly blood clot
4. Research team enlightens the reasons for severe blindness
5. Research teams uncover risk genes for multiple sclerosis
6. Research shows NPD1 protects a key component of vision
7. Researchers find pathway that controls cell size and division
8. Researchers watch antibiotics, bacteria meet at atomic level
9. Researchers discover gene responsible for Restless Legs Syndrome
10. Research study describes the role part of the brain plays in memory
11. NY Stem Cell Foundations 2nd Annual Translational Stem Cell Research Conference

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2020)... (PRWEB) , ... July 30, 2020 , ... ... prescription digital therapeutics product portfolio with a near term focus on Type 2 ... and pharma commercialization experience across multiple therapeutic areas and classes. As Chief Commercial ...
(Date:7/18/2020)... ... 17, 2020 , ... Commercial launch readiness is a critical stage in a ... cure or vaccine, the global economic downturn will only increase price pressures overall for ... and capturing full value from every product launch is critical. However, history shows that ...
(Date:7/4/2020)... ... 2020 , ... Aesthetics Biomedical (ABM), a leading aesthetics product ... only the products and treatments developed, but also the dedicated team behind the ... brands built by ABM have received several honors already for 2020, each of ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... SHREWSBURY, Mass. (PRWEB) , ... July 29, 2020 ... ... clad wire that can combine up to three different materials for use with ... can combine up to three materials to meet specific design requirements, performance, and ...
(Date:7/22/2020)... ... ... Join experts from Reed Tech , Gary Saner, Sr. Manager, Information Solutions ... live webinar on Thursday, August 13, 2020 at 11am EDT (4pm BST/UK). , ... for medical devices, the NMPA has departments dealing with medical device registration (pre-market approvals) ...
(Date:7/10/2020)... ... 08, 2020 , ... Bode Technology, a leading ... operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines high-volume clinical ... provides a turnkey solution that includes a comprehensive collection and virus-management program ...
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT World has announced the ... Squibb, the University of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia ... program, highlighting outstanding examples of how technology innovations and strategic initiatives can be ...
Breaking Biology Technology:
Cached News: