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Research strengthens link between smoking, pancreatic cancer

Researchers at Michigan State University have added yet another piece to the puzzle that links cigarette smoking with cancer of the pancreas, one of the deadliest forms of cancer.

In research published in the recent issue of the International Journal of Cancer, MSUs James Trosko and colleagues zeroed in on the mechanism by which a healthy cell turns cancerous.

Specifically, they found that the chemicals produced by the burning of tobacco products polycyclic aromatic hydrocarbons, or PAHs interfere with communication between the bodys cells. More importantly, the work showed that some of these chemicals dont necessarily initiate the cancer, but rather contribute to the promotion of it.

"These PAH chemicals are related to the multistage, multimechanism process of carcinogenesis, not by mutating the stem cell, but by triggering the stem cell thats been previously mutated to proliferate," said Trosko, a professor of pediatrics and human development. "This finding has major implications, including the possibility that dietary intervention might interrupt or even reverse the promotion of pancreatic cancers."

Until now, most scientists thought that specific PAHs produced by burning tobacco mutated genes which, in turn, triggered the cancer mechanism.

"We take issue with this interpretation," Trosko said. "We dont believe that the PAH chemicals cause mutations which then lead to cancer."

Pancreatic cancer is one of the more deadly forms of cancer, with an average survival rate of only about a year. Its projected that more than 37,000 Americans will be diagnosed with pancreatic cancer in 2007.

Trosko noted that PAHs are formed when any substance containing certain proteins is burned, including foods.

"PAHs are all over," he said. "When you grill a steak or a hamburger, for example, you get exactly the same class of chemicals."

This research is the culmination of nearly 30 years of
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Contact: Tom Oswald
oswald@msu.edu
517-432-0920
Michigan State University
8-Mar-2007


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