HOME >> BIOLOGY >> NEWS
Research teams uncover risk genes for multiple sclerosis

Two new large-scale genomic studies have honed in on the main genetic pathway associated with multiple sclerosis (MS), while also uncovering new genetic variations in the disease and suggesting a possible link between MS and other autoimmune diseases.

The first study, led by an international consortium of clinical scientists and genomics experts, incorporates the two largest collections of MS genetic information worldwide and is the first comprehensive study to investigate the overall genetic basis of MS. Its findings appear in the July 29, 2007 online edition of the New England Journal of Medicine.

Another study is being published simultaneously on the web site of Nature Genetics, and focuses on one variant in a gene called interleukin-7 receptor (IL-7R), which researchers had thought was connected to the disease and now know increases the risk of MS.

Scientists have known for 30 years that genetics play a critical role in MS, but the disease is influenced by so many different factors that it has consistently eluded us, said Stephen Hauser, MD, professor of neurology at the University of California, San Francisco and an author on both papers. It wasnt until we could map genomes and then combine the efforts of dozens of researchers, that we could put all the pieces together.

Together, he said, these two papers illustrate how scientific collaboration and the recent breakthroughs in genomic technology, which make it possible to both screen an individuals genetic architecture and understand the differences, can open up an age-old disease such as multiple sclerosis.

It is significant that the two studies used very different approaches, but both highlighted the role of IL-7R, he said.

Together, these place the IL-7R pathway at the center of understanding MS pathogenesis, Hauser said. I believe that this receptor and its interaction with regulatory T cells will now become a major focus of research on MS. '"/>

Contact: Kristen Bole
kbole@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
30-Jul-2007


Page: 1 2 3 4

Related biology news :

1. Gilbert Foundation and American Fed for Aging Research award grants on Alzheimers disease
2. Research shows skeleton to be endocrine organ
3. Research aims to identify markers for menopausal women at risk for deadly blood clot
4. Research team enlightens the reasons for severe blindness
5. Research shows NPD1 protects a key component of vision
6. Researchers find pathway that controls cell size and division
7. Researchers watch antibiotics, bacteria meet at atomic level
8. Researchers discover gene responsible for Restless Legs Syndrome
9. Research study describes the role part of the brain plays in memory
10. NY Stem Cell Foundations 2nd Annual Translational Stem Cell Research Conference
11. Researchers witness natural selection at work in dramatic comeback of male butterflies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/6/2019)... ... November 06, 2019 , ... NDA Partners Chairman ... pharmaceutical industry executive with expertise in clinical pharmacology and pharmacometrics and a widely ... data analytics, has joined the firm as an Expert Consultant. , Dr. Stanski ...
(Date:11/5/2019)... ... November 05, 2019 , ... ... solutions for drugs, biologics, gene therapies, and consumer health products, today announced it ... Hotel Sofia, Barcelona, Spain on Nov. 12 – 14, 2019. , On Wednesday, ...
(Date:11/2/2019)... ... ... Stay on top of current hot topics through free webinars presented by leading ... so be sure to register today to save your place! Participate in the discussion ... upcoming webinars: , CLINICAL OPERATIONS , November 14 – Leveraging Technology and Data to ...
Breaking Biology News(10 mins):
(Date:10/30/2019)... ... October 30, 2019 , ... ... the many roles innovation and technology play in educating the next generation of ... hands-on learning opportunities and presentations by WesternU administrators and representatives of companies working ...
(Date:10/22/2019)... ... 22, 2019 , ... nQ Medical, Inc. of Cambridge, MA, was recognized in ... which was announced at a showcase event yesterday in Los Angeles. nQ competed against ... plans, and impressive near-term growth projections to be named one of the most fundable ...
(Date:10/17/2019)... ... 16, 2019 , ... My Gene Counsel , a ... a new white paper that explores how frequently medical management guidelines have been ... and medical providers can be kept informed as changes are made. , Entitled ...
(Date:10/10/2019)... ... October 10, 2019 , ... ... network of clinical research centers in Europe. All Pratia research centers have completed ... to become trained and certified as Virtual Trial Capable and prepared to conduct ...
Breaking Biology Technology:
Cached News: