HOME >> BIOLOGY >> NEWS
Research yields new insights into the cause of diabetes

The cause of insulin-dependent, permanent, diabetes in newborn babies may be a deficiency in the enzyme Pancreatic Endoplasmic Reticulum Kinase (PERK) during a critical period of development before birth, according to a new hypothesis put forward by a team of researchers from Penn State University. In this most severe type of diabetes, individuals are unable to regulate glucose normally because they have few insulin-producing beta cells in their pancreas and the remaining cells do not produce enough insulin. Using special strains of mice bred to be PERK-deficient, the researchers demonstrated that the lack of this enzyme blocked the proliferation of beta cells, hampered the normal functioning of beta cells, and also kept beta cells from clustering into islets. "What happens during fetal development predisposes people either to be able to maintain glucose levels normally or to have diabetes," says team leader Douglas Cavener, professor and head of the Department of Biology. The research results will be published in the journal Cell Metabolism on 6 December 2006.

The team, consisting of graduate students Wei Zhang, Yulin Li and Kaori Iida, Postdoctoral Fellow Daorong Feng, and Research Assistant Professor Barbara McGrath, made use of the lab's earlier discovery that mice deficient in PERK show many parallels to human sufferers of Walcott-Rallison Syndrome (WRS), in which diabetes is combined with skeletal and growth abnormalities. The research provided an experimental model for investigating the cause of permanent neonatal diabetes that was more revealing than cell culture studies.

"Being able to develop special strains of mice that are PERK-deficient in specific organs or tissues was vital to our research," says Cavener. "These mice allowed us to discover exactly how PERK participates in the development and growth of the beta cells in the pancreas that secrete insulin. Using genetics in this way lets the organism tell you what
'"/>

Contact: Barbara K. Kennedy
science@psu.edu
814-863-4682
Penn State
5-Dec-2006


Page: 1 2 3

Related biology news :

1. Gilbert Foundation and American Fed for Aging Research award grants on Alzheimers disease
2. Research shows skeleton to be endocrine organ
3. Research aims to identify markers for menopausal women at risk for deadly blood clot
4. Research team enlightens the reasons for severe blindness
5. Research teams uncover risk genes for multiple sclerosis
6. Research shows NPD1 protects a key component of vision
7. Researchers find pathway that controls cell size and division
8. Researchers watch antibiotics, bacteria meet at atomic level
9. Researchers discover gene responsible for Restless Legs Syndrome
10. Research study describes the role part of the brain plays in memory
11. NY Stem Cell Foundations 2nd Annual Translational Stem Cell Research Conference

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... , May 16, 2017   Bridge ... health organizations, and MD EMR Systems , ... development partner for GE, have established a partnership ... Portal product and the GE Centricity™ products, including ... EMR. These new integrations will ...
(Date:4/18/2017)... Inc., a global expert in SoC-based imaging and computing solutions, has ... features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® ... be showcased during the upcoming Medtec Japan at Tokyo Big Sight ... Las Vegas Convention Center April 24-27. ... Click here for an image of the ...
(Date:4/11/2017)... 11, 2017 Crossmatch®, a globally-recognized leader ... today announced that it has been awarded a ... Activity (IARPA) to develop next-generation Presentation Attack Detection ... "Innovation has been a driving force within Crossmatch ... allow us to innovate and develop new technologies ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... ... 20, 2017 , ... Dr. Asher Kimchi, Founder and Chairman of the ... Awards at the 22nd World Congress on Heart Disease held in Vancouver, BC, Canada. ... the Distinguished Fellowship Awards. , Dr. Asher Kimchi, together with Co-Chairmen Dr. John A. ...
(Date:7/20/2017)... ... July 20, 2017 , ... Corista, a leader in ... intelligence Tuesday, July 25, during the Association of Pathology Chairs’ Jubilee Meeting in ... , Baras, Associate Director of Pathology Informatics, will present “The Digital Pathology Experience ...
(Date:7/20/2017)... (PRWEB) , ... July 20, 2017 , ... ... solution to make clinical trial sites and study participants truly unified. TrialKit, a ... compliant (FDA 21 CFR Part 11) research studies entirely on mobile devices. With ...
(Date:7/18/2017)... Basel, Switzerland (PRWEB) , ... July 18, 2017 ... ... for R&D, today announced that Merck, a leading science and technology company, has ... develop innovative therapeutics for the therapeutic areas of Oncology, Immunology, and Neurodegenerative Diseases. ...
Breaking Biology Technology:
Cached News: