Researcher looks for more targeted way to deliver cancer drugs

The future of drug design lies in finding ways to target a drug specifically to a diseased cell, or even a molecule within that cell, while leaving healthy cells and molecules unharmed.

Victor Yang, professor of pharmacy at the University of Michigan, is using natural biomolecules to deliver medication in two parts, making it more Specifically lethal to select cells.

Yang recently received a $1.28 million, five-year grant from the National Institutes of Health to study cancer drug delivery.

Yang said researchers face multiple challenges in developing new treatments for cancer, including a lack of selectivity in the cells the drugs kill and difficulty getting through the cell membrane. They can add a target to the drug and tell it to go to the liver, for example, but that doesn't solve the challenge of getting into the diseased cells and leaving healthy cells alone.

Yang's approach is to give the patient an inactive drug that zeros in on the target cells, and then to inject a separate compound that tells the drug to activate only when it reaches its target. His method can also be used to create more precise images of diseased tissue.

He is using a combination of amino acids called the TAT peptide as a carrier molecule. This positively charged molecule normally carries a protein toward the cell's membrane, which has a negative charge. Yang gives it a drug or activating compound to carry instead, and the peptide gets these molecules into the interior of the targeted cells---first the drug, and then the compound that turns it on.

The process works in experiments, though Yang said scientists are still unclear on how the peptide can get into the cell. He speculates that it may use the same tricks a virus does to invade a cell.

Yang would like to use a targeted approach on brain cancer because there is a nearly impervious membrane called the blood-brain barrier that prevents doctors from being able to directly get

Contact: Colleen Newvine
University of Michigan

Page: 1 2

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:

(Date:7/31/2020)... ... July 30, 2020 , ... BioFactura, Inc. today ... by the Joint Science & Technology Office—Chemical and Biological Defense (JSTO-CBD) of the ... and scale-up a highly efficient mammalian cell culture-based bioprocess suitable to meet surge ...
(Date:7/18/2020)... ANTONIO (PRWEB) , ... July 16, 2020 , ... ... ONE that demonstrates the effectiveness of the Invictus Medical Neoasis™ active noise control ... environment. The study reported that the Neoasis™ device attenuated the alarm sounds from ...
(Date:7/10/2020)... ... July 09, 2020 , ... Today CJ BIO announced the ... share insight on the “fifth taste” phenomenon that is revolutionizing ingredient mixes, nutritional content ... will be live on Monday, July 13, 2020 at11:00 AM (CDT) during SHIFT20, the ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... 08, 2020 , ... Bode Technology, a leading ... operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines high-volume clinical ... provides a turnkey solution that includes a comprehensive collection and virus-management program ...
(Date:7/10/2020)... ... 09, 2020 , ... In most research using the zebrafish ... formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. Over the ... using the zebrafish model to investigate the causes of leukaemia and its relationship ...
(Date:7/7/2020)... DIEGO (PRWEB) , ... July 06, 2020 , ... R3 ... new program featuring up to 200 million stem cells. Depending on the patient's condition, ... seniors in the US will die having some form of Alzheimers dementia, and the ...
(Date:7/1/2020)... ... June 29, 2020 , ... MedShift ... 40% in 2020, despite many obstacles created as a result of COVID-19. As ... for its partnered medical practices and medical manufacturers by expanding access to device ...
Breaking Biology Technology:
Cached News: