HOME >> BIOLOGY >> NEWS
Researchers at UT Southwestern discover new function for old enzyme

ly have metabolic functions, and that aconitase, one of these proteins, is essential for mitochondrial DNA maintenance and inheritance, a new function independent of its normal enzyme activity."

To determine the region of aconitase that keeps mitochondrial DNA intact, Dr. Butow's group made mutations in parts of the enzyme that are important for its catalytic activity. In spite of these mutations, aconitase still functions in the maintenance of mitochondrial DNA. The researchers concluded that aconitase's role in protecting the mitochondrial genome is independent of its role in making energy, giving a new face to the long-known enzyme.

Genes in the cell's nucleus code for aconitase, and once made, the protein is shuttled to the mitochondria to serve its functions. According to Dr. Butow, aconitase may participate in an internal cell communication system known as retrograde signaling.

Retrograde signaling serves as a status-check in cells, where the mitochondria signal to the nucleus if something is wrong and when things are better again. By protecting the mitochondrial DNA, aconitase may be part of the "A-OK" signal after the cell experiences stress.

The role of aconitase in stabilizing the mitochondrial genome may be an evolutionary adaptation where the mitochondria co-opts a nuclearly encoded protein to ensure survival of its genome, said Dr. Butow. "The cell takes care of the nucleus, because that is where its genome is," he said, "but the mitochondrial genome is not looked after. It has to take care of itself."

Other UT Southwestern researchers who participated in the study are lead author Dr. Xin Jie Chen, assistant professor of molecular biology, and Xiaowen Wang, research assistant in molecular biology. Dr. Brett A. Kaufmann, a former graduate student at UT Southwestern now with the Montreal Neurological Institute, also contributed.


'"/>

Contact: Megha Satyanarayana
megha.saty@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
3-Feb-2005


Page: 1 2

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/17/2019)... ... 15, 2019 , ... RCH Solutions (RCH), a ... companies, announces the availability of new specialty advisory practice, a Public Cloud Managed ... emerging bio-pharma companies interested in achieving specific outcomes related to public Cloud adoption. ...
(Date:7/9/2019)... ... July 09, 2019 , ... ... Research into its incubator program. The founder and CEO of Tx Genetic, Helen ... lives of those suffering from epithelial connective tissue disorders. , “We are pleased ...
(Date:6/25/2019)... ... 25, 2019 , ... ActX has launched a medical genetic ... 23andMe, customers can get access to professionally reviewed genetic screening similar to what ... and Health + Ancestry customers., With the ActX + 23andMe service, both 23andMe ...
Breaking Biology News(10 mins):
(Date:7/17/2019)... ... 16, 2019 , ... Quidel is the market leader in ... Roche and Siemens Healthineers and Response Biomedical also are among the top companies. ... Point-of-Care (POC) Diagnostics . , Quidel is a market leader in rapid immunoassays ...
(Date:6/26/2019)... ... , ... Alice Branton today released research results from preclinical trials on the ... can prove to be beneficial for treating Hypomagnesemia. , The preclinical trial shows:, ... size , Over 142% increase in particle size , Over ...
(Date:6/11/2019)... JUPITER, Fla. (PRWEB) , ... June 10, 2019 ... ... breakthroughs in science and technology in an upcoming episode, scheduled to broadcast 4Q/2019. ... of the Eppendorf Group) and will educate viewers about how its technology facilitates ...
(Date:6/6/2019)... ... 2019 , ... WCCT Global, Inc ., a full-service early phase contract ... will be receiving 3 awards at the 2019 CRO Leadership Awards, to be held ... categories of overall Quality and Compatibility (Access to desired markets, cultural fit, timely project ...
Breaking Biology Technology:
Cached News: