HOME >> BIOLOGY >> NEWS
Researchers at Vanderbilt-Ingram Cancer Center uncover clue to explain invasive brain tumors

Researchers at the Vanderbilt-Ingram Cancer Center have uncovered a clue to explain the invasive nature of an aggressive kind of brain tumor called glioblastoma multiforme, or gliomas, and their findings are published in this week's online edition of the journal Oncogene.

Reid Thompson, M.D., director of Neurosurgical Oncology, and his colleague, Moneeb Ehtesham, M.D., assistant professor of Neurological Surgery and Cancer Biology, found a key receptor plays a role in the spread of this tumor.

"We looked at CXCR4, a molecule which has been shown to play a role in other cancers, and found that the more metastatic aggression relates to this molecule. So, we looked at whether this molecule governed this invasion in gliomas," said Ehtesham.

CXCR4 is a receptor that is found in white blood cells and has been shown to play a key role in regulating the movement of cells in the immune system. Finding something to inhibit CXCR4 could potentially lead to treatment options to prevent cancerous cells from moving to other organs.

In animal models, Thompson and Ehtesham found CXCR4 can, in fact, be linked to cell invasion in glioblastoma. "If we look at a brain cancer model in rodents we can see a difference in CXCR4 expression in invasive and non-invasive cells. We found CXCR4 was expressed in the non-invasive cells, but was much higher in invasive cells, or cells from the core of the tumor and cells that had migrated away," said Ehtesham. Thompson said it was significantly higher, "up to thirty- to fortyfold higher in the invasive cells," he added.

Next, Thompson and Ehtesham looked at CXCR4 more closely, in dish studies. They wanted to determine whether cells that have CXCR4 invade more than cells without the molecule. They induced glioblastoma and forced the cells to migrate, comparing migrating brain tumor cells with the cells at the origin of the cancer. Their findings were consistent with the animal studies -- CXCR4 was again muc
'"/>

Contact: Heather Hall
heather.l.hall@vanderbilt.edu
615-936-7245
Vanderbilt University Medical Center
10-Jan-2006


Page: 1 2

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/25/2019)... ... August 23, 2019 , ... BioInformatics, part of Science ... Experts-on-Demand. The service helps connect companies with a network of thousands of life ... technology, and medicine is moving faster than ever, and we have built a ...
(Date:8/21/2019)... ... August 21, 2019 , ... AbSci, a revolutionary ... and low-cost biomanufacturing of complex protein therapeutics, today announced the appointment of Fred ... Advisory Board, Dr. Larimore brings more than 30 years of experience in biopharmaceutical ...
(Date:8/21/2019)... Va. (PRWEB) , ... August 20, 2019 , ... ... customer experience for the second time since BioInformatics first fielded the survey in ... 2019: Life Science Customer Experience , from BioInformatics, part of Science and Medicine ...
Breaking Biology News(10 mins):
(Date:7/9/2019)... ... July 08, 2019 , ... Today, at the BIO World ... Corn Growers Association (NCGA) announced the winners of the Consider Corn Challenge II. ... process using field corn to produce biobased materials. , “Corn is a sustainable, ...
(Date:6/26/2019)... (PRWEB) , ... June 26, 2019 , ... Alice Branton ... treatment on improving physicochemical properties of Magnesium Gluconate, which can prove to be beneficial ... 125% alteration of characteristic differentiation peak, change in crystallite size , Over ...
(Date:6/12/2019)... ... June 12, 2019 , ... Leak Detection Associates (LDA), the ... Biotechnology, Medical Device and Food Packaging Industries, is excited to announce that a ... exclusive rights for Zillion to represent LDA in all of China. , ...
(Date:6/11/2019)... ... 10, 2019 , ... DeepDyve and IOP ... to DeepDyve’s rental service for peer-reviewed journals. , IOPP’s portfolio represents an ... 20 million articles, sourced from more than 15,000 journals. , “By partnering with ...
Breaking Biology Technology:
Cached News: