Researchers call for studies on role of BRCA1 mutations in chemotherapy response

Loss of BRCA1 function is associated with sensitivity to DNA-damaging chemotherapy and may also be associated with resistance to taxane-based chemotherapy. However, prospective clinical studies are needed to evaluate the role of BRCA1 in chemotherapy response, concludes a new review in the November 17 issue of the Journal of the National Cancer Institute.

BRCA1 mutations account for only 5% of breast and ovarian cancers, but loss-of-function mutations in the BRCA1 gene confer up to an 82% risk of breast cancer and up to a 54% risk of ovarian cancer. Because BRCA1 is involved in DNA repair, loss of a functioning BRCA1 gene may make a cell more vulnerable to chemotherapy agents that damage DNA, such as platinum-based compounds. In addition, BRCA1 has also been shown to be involved in the regulation of cell division, and loss of the gene has been proposed to protect a cell against spindle poisons, a group of chemotherapy agents, such as taxanes and vinca alkaloids, that disrupt cell division.

To determine whether the level of BRCA1 function in a patient could be used to predict response to chemotherapy for breast and ovarian cancers, D. Paul Harkin, B.Sc., Ph.D., and Richard D. Kennedy, M.D., Ph.D., of The Queen's University of Belfast in Northern Ireland, and colleagues reviewed published preclinical and clinical evidence. Preclinical studies included research in both animal models and cell lines. Clinical studies were all retrospective in nature, because no prospective trials have been designed to study the role of BRCA1 in chemotherapy response.

The researchers found that BRCA1 inactivation through mutation appears to confer sensitivity to DNA-damaging chemotherapeutic drugs commonly used to treat breast and ovarian cancers. However, preclinical evidence suggests that BRCA1 function is necessary for spindle poisons to work. The authors recommend that prospective studies be conducted to evaluate BRCA1 expression and chemotherapeutic res

Contact: Sarah L. Zielinski
Journal of the National Cancer Institute

Page: 1 2

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:

(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. (NASDAQ: ... announces the filing of its 2016 Annual Report on Form 10-K ... Commission. ... 10-K is available in the Investor Relations section of the Company,s ... the SEC,s website at http://www.sec.gov . 2016 Year ...
(Date:4/11/2017)... BROOKLYN, N.Y. , April 11, 2017 /PRNewswire-USNewswire/ ... identical fingerprints, but researchers at the New York ... University College of Engineering have found that partial ... fingerprint-based security systems used in mobile phones and ... previously thought. The vulnerability lies in ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... to expand at a CAGR of 25.76% during the ... is the primary factor for the growth of the ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem ... technology, application, and geography. The stem cell market of ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ., ... a Webinar titled, “Pathology is going digital. Is your lab ready?” with Dr. ... best practices and how Proscia improves lab economics and realizes an increase in ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today announced ... to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B ... to cross the cell membrane and bind intracellular STAT3 and inhibit its function. ...
(Date:10/10/2017)... 2017 International research firm Parks Associates announced today ... the TMA 2017 Annual Meeting , October 11 in ... home security market and how smart safety and security products impact the ... Parks Associates: Smart Home Devices: ... "The residential security market has experienced ...
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer ... first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With ... with the challenge of how to continue to feed a growing nation. At the ...
Breaking Biology Technology:
Cached News: