HOME >> BIOLOGY >> NEWS
Researchers create model of cancer-preventing enzyme, study how it works

COLUMBIA, Mo. -- Researchers at the University of Missouri-Columbia recently created a model of proline dehydrogenase, an important cancer-preventing enzyme in the human body, and analyzed how it works. A paper detailing their results was published today in the Journal of Biological Chemistry.

Proline dehydrogenase is important because it plays a role in apoptosis, the process of cell death, by enabling the creation of superoxide, a highly reactive electron-rich oxygen species. Superoxide is involved in the destruction of damaged cells and therefore is important in preventing the development and spread of cancer. The protein proline dehydrogenase "opens up to allow oxygen to steal electrons" and create a superoxide, said Tommi A. White, an MU doctoral student in biochemistry.

White worked with John J. Tanner, professor of chemistry and biochemistry in MUs College of Arts and Science, and Navasona Krishnan, a doctoral student at the Unviersity of Nebraska-Lincoln, and Donald F. Becker, an associate professor at the University of Nebraska-Lincoln, to create the first model of proline dehydrogenase. Because the human form of this enzyme is difficult to work with, the team studied proline dehydrogenase from the bacteria Thermus thermophilus. They used bioinformatics and biochemical studies to show that this enzyme is functionally similar to the human version, so their results can be generalized to the human version, as well as the bacterial version.

Using X-ray crystallography and biochemical analysis, the team created a model of proline dehydrogenase that can tell scientists more about the molecules structure and functions.

"The three-dimensional model tells us a lot about the structure of the molecules and helps us understand how they work," Tanner said. "This protein is important in cancer prevention because it enables the creation of superoxide, which aid in cell death. Cells arent meant to live forever, and at
'"/>

Contact: Katherine Kostiuk
kostiukk@missouri.edu
573-882-3346
University of Missouri-Columbia
11-May-2007


Page: 1 2

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... August 05, 2020 , ... Regenative Labs has received approval from ... and ProText™, making them the first Wharton’s jelly allografts to be assigned a Q ... company’s solutions are the first Wharton’s jelly allograft product to be recognized as a ...
(Date:7/22/2020)... ... July 21, 2020 , ... ... innovation in technology and compliance, announces a new solution to manage regulated workloads ... every layer of their technology stack complies with FDA and global regulations. USDM's ...
(Date:7/10/2020)... CHICAGO (PRWEB) , ... July 09, 2020 , ... Today ... Umami Advantage, which will share insight on the “fifth taste” phenomenon that is revolutionizing ... snacks. The Umami Advantage will be live on Monday, July 13, 2020 at11:00 AM ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... (PRWEB) , ... July 17, 2020 , ... ... global consulting firm for the life sciences and food industries, is pleased to ... Director of Clinical Research – Business Development. , Charles is an accomplished and ...
(Date:7/10/2020)... ... 2020 , ... Sentien Biotechnologies, Inc., a clinical-stage biotechnology company ... Nissenson, M.D., F.A.C.P., as its Chief Medical Officer. Dr. Nissenson will join ... Dr. Nissenson serves as an Emeritus Professor of Medicine at the David ...
(Date:7/1/2020)... ... 29, 2020 , ... The Interlocal Purchasing System (TIPS), a ... recently named BioFit Engineered Products an Awarded Vendor. Awarded Vendor status ... cafeteria tables, book trucks and carts at discounted pricing without the delay and ...
(Date:6/28/2020)... HILL, Conn. (PRWEB) , ... June 25, 2020 ... ... company formed to advance photodynamic therapy for treating cancer, today announced the company ... New York (“Roswell Park”). The agreement provides Lumeda globally exclusive rights to ...
Breaking Biology Technology:
Cached News: