HOME >> BIOLOGY >> NEWS
Researchers develop new strategy for the treatment of CML

RICHMOND, Va. (Jan. 17, 2007) -- Virginia Commonwealth University Massey Cancer Center researchers have identified an approach to enhance the activity of a new anti-cancer agent that has already shown impressive efficacy in the treatment of chronic myelogenous leukemia.

Chronic myelogenous leukemia, or CML, is a cancer of the bone marrow caused by a specific genetic abnormality and is one of the more common forms of leukemia. Imatinib mesylate (Gleevec) is a highly effective anti-cancer agent that has revolutionized the course of therapy for patients with CML. It works by inhibiting the activity of a mutant protein, known as Bcr/ABl, which is responsible for this disease. However, despite initial success, patients eventually become resistant to imatinib mesylate.

According to Steven Grant, M.D., Massey's associate director for translational research and co-leader of the cancer center's cancer cell biology program, and senior author of the study, resistance to imatinib mesylate has prompted the development of newer generation inhibitors, such as a compound known as dasatinib, which are not only considerably more potent than imatinib mesylate, but also are active against cells expressing many of the mutations that make them resistant to the latter agent. Dasatinib also inhibits another important survival protein known as Src. However, Grant said that not all patients respond to dasatinib, and the risk remains that patients will develop resistance to this agent as well.

To address this problem, Grant and colleagues examined the effects of combining dasatinib with PD184352, another clinically relevant small molecule inhibitor of a critical cellular survival pathway that inactivates an important survival protein known as ERK1/2 (extracellular-signal regulating kinase1/2). The article was pre-published as a First Edition Paper in Blood, the journal of the American Society of Hematology, which appeared online Jan. 11.

By block
'"/>

Contact: Sathya Achia-Abraham
sbachia@vcu.edu
804-827-0890
Virginia Commonwealth University
17-Jan-2007


Page: 1 2

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/5/2018)... N.C. (PRWEB) , ... October 05, 2018 , ... ... Nutrition North America, Inc. (AHN), is announcing a 10% price increase across all ... AHN produces amino acids — the building blocks of protein — for the ...
(Date:10/5/2018)... YORBA LINDA, Calif. (PRWEB) , ... October 04, 2018 , ... ... inaccurate results of some of the tests such as cardiac troponin has serious clinical ... US population, although the exact prevalence is still unknown. , High dose of ...
(Date:10/2/2018)... GIBRALTAR, Gilbraltar (PRWEB) , ... October 02, 2018 , ... ... gaps between research, development, and access to stem cell therapy, has launched the pre-sale ... company is building a dual blockchain-based platform that will connect patients and stem cell ...
Breaking Biology News(10 mins):
(Date:10/16/2018)... ... October 16, 2018 , ... Infinity Healing Center, along ... a revolutionary technology that effectively treats pain, reduces the need for opioids, and ... how technology using photobiomodulation (PBM) has been effective for the treatment of medical ...
(Date:10/11/2018)... ... October 11, 2018 , ... Umbilical cord ... leukemia, lymphoma, sickle cell anemia, among others, and the medical industry has been ... new e-book provides expert advice on ways to maintain the integrity and the ...
(Date:10/5/2018)... PIPERSVILLE, Pa. (PRWEB) , ... October 04, 2018 ... ... launching a new brand identity and website that elevates the company’s brand identity ... as EARTHRES, the company offers a broader range of engineering expertise and related ...
(Date:10/2/2018)... ... October 02, 2018 , ... The Alliance ... teams have initiated validation of standards and testing of procedures for voluntary accreditation ... Larry Kennedy, ACRES VP for Quality Management Systems and Chief Quality Officer, is ...
Breaking Biology Technology:
Cached News: