HOME >> BIOLOGY >> NEWS
Researchers discover 'acquired' DNA key to certain bacterial infection

CORVALLIS, Ore. -- Researchers announced this week the discovery of a mechanism by which Mycobacterium avium a bacterium which can result in serious lung infections and is prevalent in emphysema and AIDS patients among others infects tissue cells or macrophages and thus compromises the bodys immunity.

Results of the study, led by researchers at Oregon State University, will be published online this week in the Proceedings of the National Academy of Sciences. Other co-authors were from the University of Nebraska.

The key to the bacteriums ability to enter environmental amoebas and ultimately humans is an island of genetic material acquired through evolution from another bacterium, according to Luiz E. Bermudez, a professor of biomedical sciences in OSUs College of Veterinary Medicine and an author of the study.

Without these acquired genes, the bacterium is very inefficient in infecting environmental amoeba, which is the environmental host, Bermudez said. In fact, its efficiency is close to zero. But with this island of acquired genetic material, the bacterium finds a way to get inside the cells and it takes control, not the phagocyte.

Phagocytes are cells that engulf and digest pathogens and cellular debris, and in humans serve as the bodys initial immune response.

The researchers did not find a similar island of acquired genetic material in two similar bacteria, Mycobacterium tuberculosis and Mycobacterium paratuberculosis, which causes Johnes disease.

M. avium exists in the environment and is thought to infect humans when the infected environmental hosts amoebas are inhaled or swallowed.

Incidence of M. avium as a cause of syndromes may be decreasing because of changes in treatment for HIV-infected patients, according to the Centers for Disease Control and Prevention, which estimates that 1 out of 100,000 persons may be affected. However, CDC also notes that the bacteriums resistance
'"/>

Contact: Luiz Bermudez
luiz.bermudez@oregonstate.edu
541-737-6538
Oregon State University
18-Jun-2007


Page: 1 2

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/2/2020)... , ... July 01, 2020 , ... ... its phase 1a findings of Neihulizumab, a biologic for the treatment of steroid-refractory ... 2020. Led by hemato-oncologist Dr. Paul J Martin of the Fred Hutchinson Cancer ...
(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, a registered 501(c)(3) ... and aggressive adult brain cancer—announced today the appointments of its first Senior Fellows: ... supporting the organization’s initiatives and overall vision. , "Senior Fellows are more than ...
(Date:6/25/2020)... , ... June 24, 2020 , ... ... enterprise software and software-driven clinical data services that accelerate drug development, is collaborating ... selinexor, an XPO1 inhibitor, in hospitalized patients with severe COVID-19. This is the ...
Breaking Biology News(10 mins):
(Date:6/28/2020)... ... June 25, 2020 , ... With ... a vaccine or drug treatment. In an effort to better understand the cellular ... the world’s largest imaging dataset portraying therapeutic compound effects from over 1,600 approved ...
(Date:6/23/2020)... ... June 23, 2020 , ... DeCurtis Corporation, ... announced today that Derek Fournier has been appointed CEO and President. Founder and ... effective immediately. , “DeCurtis Corporation has been on an incredible journey for ...
(Date:6/19/2020)... ... June 18, 2020 , ... The Vitaspace project was founded ... forces to radically prolong life and find a way (medicine or technology) that will ... was supported by various scientists from all over the world, doctors, and all people ...
(Date:6/11/2020)... ... June 09, 2020 , ... Reducing carbon emissions has ... From the Paris Agreement to stock market dips, ways to reduce CO2 is something ... to their portfolio. Most of the biofuels being produced today are created from recycled ...
Breaking Biology Technology:
Cached News: