HOME >> BIOLOGY >> NEWS
Researchers discover communication signal for tissue development

Troy, N.Y. -- Researchers at Rensselaer Polytechnic Institute have discovered a communication signal between cells that plays an important role in cell adhesion and detachment. The finding provides new information about how cells and tissues determine when to let go from surfaces during new growth, according to the researchers.

"Our discovery of this new signaling pathway adds to fundamental information about how cells work together during the remodeling of tissues and organs," said Andrea Page-McCaw, assistant professor of biology at Rensselaer. "This finding also may provide clues about the basic mechanisms of inflammation and wound healing in vertebrates."

Page-McCaw's laboratory studies the fruit fly as a model system to better understand a group of genetic enzymes called matrix metalloproteinases (MMPs). Fruit flies have two distinct MMPs, compared to 22 such enzymes found in humans and mice. In previous work, Page-McCaw found that both MMPs present in fruit flies are critical to their survival.

"Although MMP enzymes have been linked to disease progression, their normal function is to help in tissue growth and wound healing," Page-McCaw said. "MMP research eventually could lead to therapeutics for a range of illnesses, including cancer and arthritis."

Page-McCaw studies development and remodeling of the airway system, or tracheae, in fruit fly larvae with normal and mutant MMPs to determine how those genes contribute to normal function. In this work, she and her colleagues found that one of the MMPs chops off a piece of a protein called Ninjurin A, which is located at the surfaces of cells. The liberated piece of Ninjurin A protein then signals to other cells that it is time to detach from their surface, both in isolated cells grown in culture and in whole flies. When tracheal cells fail to detach from the insect exoskeleton, the tracheae do not grow properly and break.


'"/>

Contact: Tiffany Lohwater
lohwat@rpi.edu
518-276-6542
Rensselaer Polytechnic Institute
12-Jul-2006


Page: 1

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
(Date:1/22/2015)... YORK and POINT ROBERTS, Washington ... news source covering leading sectors including technology and tech stocks, ... Privacy marketplace featuring master pickpocket and security consultant Apollo ... is stolen and talks about the Wocket™ biometric smart wallet, ...
(Date:1/22/2015)... N.C. , Jan. 22, 2015 Infinisource has launched ... of the G2 model. The G2 sets a higher standard ... iSolved human capital management solution. With plug-and-play installation, touch screen ... time clock provides a robust time collection solution for the ...
(Date:12/19/2014)... 18, 2014 Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ... 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - ... http://photos.prnewswire.com/prnh/20130307/600769 Following the ... fingerprint reading feature with the iPhone 5S. It is ...
Breaking Biology News(10 mins):Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3Infinisource's NXG series sets new time clock standard 2iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2
(Date:1/22/2015)... January 22, 2015 Crystal Diagnostics (CDx) Xpress ... it has received AOAC-PTM Certifications for the six non-O157 Shiga ... O145; collectively referred to as STEC or the “Big-6”) as ... forming unit (cfu) per 325 g of raw ground beef ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Selexis SA, ... mammalian Research Cell Banks (RCBs) used for drug discovery ... Cell Banks will include Next-Generation Sequencing (NGS) ... architecture de-risks biologic manufacturing by ensuring the integrity of ...
(Date:1/22/2015)... Jan. 22, 2015   GenoSpace , a precision medicine software ... enable the broad use of genomic, imaging and other biomedical ... of Michelle Munson , CEO of Aspera, an IBM ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 "We are ...
(Date:12/24/2014)... 2014  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical ... that the Company closed its previously announced private ... Jack W. Schuler , Birchview Fund LLC and ... before offering expenses.  The proceeds will be used ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2GenoSpace Expands Board with Appointment of Michelle Munson 2Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
Cached News: