HOME >> BIOLOGY >> NEWS
Researchers discover communication signal for tissue development

Troy, N.Y. -- Researchers at Rensselaer Polytechnic Institute have discovered a communication signal between cells that plays an important role in cell adhesion and detachment. The finding provides new information about how cells and tissues determine when to let go from surfaces during new growth, according to the researchers.

"Our discovery of this new signaling pathway adds to fundamental information about how cells work together during the remodeling of tissues and organs," said Andrea Page-McCaw, assistant professor of biology at Rensselaer. "This finding also may provide clues about the basic mechanisms of inflammation and wound healing in vertebrates."

Page-McCaw's laboratory studies the fruit fly as a model system to better understand a group of genetic enzymes called matrix metalloproteinases (MMPs). Fruit flies have two distinct MMPs, compared to 22 such enzymes found in humans and mice. In previous work, Page-McCaw found that both MMPs present in fruit flies are critical to their survival.

"Although MMP enzymes have been linked to disease progression, their normal function is to help in tissue growth and wound healing," Page-McCaw said. "MMP research eventually could lead to therapeutics for a range of illnesses, including cancer and arthritis."

Page-McCaw studies development and remodeling of the airway system, or tracheae, in fruit fly larvae with normal and mutant MMPs to determine how those genes contribute to normal function. In this work, she and her colleagues found that one of the MMPs chops off a piece of a protein called Ninjurin A, which is located at the surfaces of cells. The liberated piece of Ninjurin A protein then signals to other cells that it is time to detach from their surface, both in isolated cells grown in culture and in whole flies. When tracheal cells fail to detach from the insect exoskeleton, the tracheae do not grow properly and break.


'"/>

Contact: Tiffany Lohwater
lohwat@rpi.edu
518-276-6542
Rensselaer Polytechnic Institute
12-Jul-2006


Page: 1

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
(Date:11/18/2014)... , Nov. 18, 2014  The Secure Identity ... Association today jointly announce the formation of The ... of its Identity and Biometric Entry and ... Framework received official support from BORDERPOL, the international ... improve and provide expertise regarding border security, traveler ...
(Date:11/12/2014)... Fla. , Nov. 12, 2014 Crossmatch™, ... today that its U.are.U ® fingerprint readers have ... chain in Central Mexico . The ... 2014 to eliminate payroll issues caused by employees clocking ... installing the U.are.U fingerprint readers, Montparnasse relied on paper ...
(Date:11/7/2014)... November 6, 2014 Leading Biometric companies ... mobile security revolutionizing online transactions.  Companies in focus today are: ... (NYSE: BABA ), Google Inc. (NASDAQ: ... Inc. (NASDAQ: EBAY ) and MasterCard Inc. (NYSE: ... and NXTDW), a biometric authentication company focused on the growing ...
Breaking Biology News(10 mins):Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6
(Date:11/21/2014)... , Nov. 20, 2014 Polaris Group ... dosed in its Phase 1 trial of ADI-PEG ... the treatment of malignant pleural mesothelioma (MPM) and ... conducting clinical trials on ADI-PEG 20, both as ... the treatment of several other indications, including breast ...
(Date:11/18/2014)... 17, 2014 RPS Diagnostics (RPS®) ... – today announces its third annual partnership of ... Get Smart About Antibiotics Week from November 17-23. ... national campaign designed to highlight the coordinated efforts ... non-profit and for-profit partners to provide education about ...
(Date:11/18/2014)... 18, 2014 American Process Inc. ... formed a partnership with researchers at Georgia Institute ... Technology, and the USDA’s Forest Products Laboratory to ... nanocellulose. Nanocellulose is a rapidly emerging high performance ... project is to replace heavy steel structures within ...
(Date:11/18/2014)... PARK, Calif. , Nov. 18, 2014 /PRNewswire/ ... biotechnology company in the emerging field of regenerative ... program, AST-OPC1 (oligodendrocyte progenitor cells) for complete cervical ... one of ten "Top Advanced Therapies Projects to ... are delighted to receive this significant industry honor, ...
Breaking Biology Technology:Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 2RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 3American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 2American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 3Asterias Biotherapeutics Named as a "Top Advanced Therapies Projects to Watch" and Will Present at the Therapeutic Area Partnerships Conference 2Asterias Biotherapeutics Named as a "Top Advanced Therapies Projects to Watch" and Will Present at the Therapeutic Area Partnerships Conference 3
Cached News: