HOME >> BIOLOGY >> NEWS
Researchers discover how compounds prevent viruses from entering cells

Compounds called defensins--known to prevent viruses from entering cells--appear to do so by preventing the virus from merging to cells' outer membrane, according to a study by researchers at the National Institute of Child Health and Human Development and the National Heart Lung and Blood Institute, both of the National Institutes of Health, and the University of California at Los Angeles.

The study, appearing in the September 11 Nature Immunology, also received funding from NIH's National Center for Research Resources.

"This discovery provides a basic understanding of a first-line defense against such viruses as HIV and the influenza virus," said Duane Alexander, M.D., Director of the NICHD. "This finding may ultimately lead to new strategies for preventing viral illness, and to increased understanding of why some individuals are more resistant to certain kinds of viral infection than are other individuals."

The means by which many viruses infect a cell is a two-step process, said the study's senior author, Leonid V. Chernomordik, Ph.D., Head of NICHD's Section on Membrane Biology in the Laboratory of Cellular and Molecular Biophysics. First, the membrane of the virus' outer coating, or envelope, must attach, or bind to, the outer membrane of the cell. After this attachment has taken place, the viral envelope membrane combines with, or fuses to, the cell membrane. After the two membranes have fused, the virus inserts its genetic material into the cell.

Defensins are produced by cells that are among the first to come in contact with viruses, Dr. Chernomordik explained. Such cells include leukocytes, a type of immune cell, and epithelial cells, which line the surfaces of many organs and tissues.

In the current study, the researchers studied epithelial cells from the inner surface of the lungs. The researchers discovered that defensins block the influenza virus entry into cells by preventing the fusion of viral and cell m
'"/>

Contact: Robert Bock or Marianne Glass Miller
bockr@mail.nih.gov
301-496-5133
NIH/National Institute of Child Health and Human Development
15-Sep-2005


Page: 1 2 3

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/23/2017)... , Jan. 23, 2017  The latest mobile ... smartphone prices have dropped dramatically. The quarterly average price ... 2013 to $276 in Q4 2016.  There are now ... price of $116, up from just 28 a year ... According to Maxine Most , Acuity Market ...
(Date:1/19/2017)... 2017 Sensory Inc ., a ... for consumer electronics, and i nnerCore ... cybersecurity solutions, today announced a global partnership that ... worldwide to bolster security of data sensitive mobile ... authentication platforms they offer, innerCore now offers its ...
(Date:1/13/2017)... Jan. 13, 2017 Sandata Technologies, LLC, ... the homecare industry, including Electronic Visit Verification™ (EVV™), ... Justin Jugs, as Senior Vice President of Product ... years of homecare experience to Sandata, where he ... plans to align Sandata,s suite of solutions with ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... , Feb 22, 2017 ... of the "Global Biological Crop Protection (Bio-Pesticide) Market-By Type, By ... (2016-2021)" report to their offering. ... Global Biological Crop Protection Market is forecasted ... The strong growth in biopesticide or biological crop protection market ...
(Date:2/22/2017)... 2017 Aethlon Medical, Inc. (Nasdaq: ... that validated the ability of the Aethlon Hemopurifier® to ... mortality in immune-suppressed sepsis patients and also contribute to ... objective of the study was to validate the ... (EBV) and Herpes Simplex virus 1 (HSV1) by the ...
(Date:2/22/2017)... ... February 22, 2017 , ... Pharma and biotech ... as European director. Operating from Pennside’s Zurich headquarters, Pennside Partners, GmbH, Mr. Perkins ... Pennside after more than a decade with leading market research firm, GfK. He ...
(Date:2/22/2017)... TRIANGLE PARK, N.C., Feb. 22, 2017  United Therapeutics ... its financial results for the fourth quarter and ... 2016 financial results reflect continued growth as net ... million," said Martine Rothblatt, Ph.D., United Therapeutics, Chairman ... our ability to develop and advance our growing ...
Breaking Biology Technology:
Cached News: