HOME >> BIOLOGY >> NEWS
Researchers discover how compounds prevent viruses from entering cells

Compounds called defensins--known to prevent viruses from entering cells--appear to do so by preventing the virus from merging to cells' outer membrane, according to a study by researchers at the National Institute of Child Health and Human Development and the National Heart Lung and Blood Institute, both of the National Institutes of Health, and the University of California at Los Angeles.

The study, appearing in the September 11 Nature Immunology, also received funding from NIH's National Center for Research Resources.

"This discovery provides a basic understanding of a first-line defense against such viruses as HIV and the influenza virus," said Duane Alexander, M.D., Director of the NICHD. "This finding may ultimately lead to new strategies for preventing viral illness, and to increased understanding of why some individuals are more resistant to certain kinds of viral infection than are other individuals."

The means by which many viruses infect a cell is a two-step process, said the study's senior author, Leonid V. Chernomordik, Ph.D., Head of NICHD's Section on Membrane Biology in the Laboratory of Cellular and Molecular Biophysics. First, the membrane of the virus' outer coating, or envelope, must attach, or bind to, the outer membrane of the cell. After this attachment has taken place, the viral envelope membrane combines with, or fuses to, the cell membrane. After the two membranes have fused, the virus inserts its genetic material into the cell.

Defensins are produced by cells that are among the first to come in contact with viruses, Dr. Chernomordik explained. Such cells include leukocytes, a type of immune cell, and epithelial cells, which line the surfaces of many organs and tissues.

In the current study, the researchers studied epithelial cells from the inner surface of the lungs. The researchers discovered that defensins block the influenza virus entry into cells by preventing the fusion of viral and cell m
'"/>

Contact: Robert Bock or Marianne Glass Miller
bockr@mail.nih.gov
301-496-5133
NIH/National Institute of Child Health and Human Development
15-Sep-2005


Page: 1 2 3

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... MELBOURNE, Florida , April 11, 2017 ... "Company"), a security technology company, announces the appointment of independent ... John Bendheim to its Board of Directors, furthering the ... ... behalf of NXT-ID, we look forward to their guidance and ...
(Date:4/5/2017)... SEATTLE , April 5, 2017  The Allen ... the Allen Cell Explorer: a one-of-a-kind portal and dynamic ... large-scale 3D imaging data, the first application of deep ... edited human stem cell lines and a growing suite ... the platform for these and future publicly available resources ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... anticipated to expand at a CAGR of 25.76% during ... diseases is the primary factor for the growth of ... report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global ... product, technology, application, and geography. The stem cell market ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... HILLS, Calif. , Oct. 11, 2017  SkylineDx today ... (ICR) and University of Leeds ... risk-stratify patients with multiple myeloma (MM), in a multi-centric Phase ... University of Leeds is the sponsor ... and ICR will perform the testing services to include high-risk ...
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building and ... rebranding initiative announced today. The bold new look is part of a transformation ... moves into a significant growth period. , It will also expand its service offering ...
(Date:10/10/2017)... Oct. 10, 2017 International research firm Parks Associates ... speak at the TMA 2017 Annual Meeting , October 11 in ... the residential home security market and how smart safety and security products ... Parks Associates: Smart ... "The residential security market ...
(Date:10/9/2017)... , Oct. 9, 2017  BioTech Holdings announced ... by which its ProCell stem cell therapy prevents ... ischemia.  The Company, demonstrated that treatment with ProCell ... limbs saved as compared to standard bone marrow ... HGF resulted in reduction of therapeutic effect.  ...
Breaking Biology Technology:
Cached News: