HOME >> BIOLOGY >> NEWS
Researchers discover how compounds prevent viruses from entering cells

Compounds called defensins--known to prevent viruses from entering cells--appear to do so by preventing the virus from merging to cells' outer membrane, according to a study by researchers at the National Institute of Child Health and Human Development and the National Heart Lung and Blood Institute, both of the National Institutes of Health, and the University of California at Los Angeles.

The study, appearing in the September 11 Nature Immunology, also received funding from NIH's National Center for Research Resources.

"This discovery provides a basic understanding of a first-line defense against such viruses as HIV and the influenza virus," said Duane Alexander, M.D., Director of the NICHD. "This finding may ultimately lead to new strategies for preventing viral illness, and to increased understanding of why some individuals are more resistant to certain kinds of viral infection than are other individuals."

The means by which many viruses infect a cell is a two-step process, said the study's senior author, Leonid V. Chernomordik, Ph.D., Head of NICHD's Section on Membrane Biology in the Laboratory of Cellular and Molecular Biophysics. First, the membrane of the virus' outer coating, or envelope, must attach, or bind to, the outer membrane of the cell. After this attachment has taken place, the viral envelope membrane combines with, or fuses to, the cell membrane. After the two membranes have fused, the virus inserts its genetic material into the cell.

Defensins are produced by cells that are among the first to come in contact with viruses, Dr. Chernomordik explained. Such cells include leukocytes, a type of immune cell, and epithelial cells, which line the surfaces of many organs and tissues.

In the current study, the researchers studied epithelial cells from the inner surface of the lungs. The researchers discovered that defensins block the influenza virus entry into cells by preventing the fusion of viral and cell m
'"/>

Contact: Robert Bock or Marianne Glass Miller
bockr@mail.nih.gov
301-496-5133
NIH/National Institute of Child Health and Human Development
15-Sep-2005


Page: 1 2 3

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/12/2016)... May 12, 2016 WearablesResearch.com , a ... the overview results from the Q1 wave of its ... wave was consumers, receptivity to a program where they ... a health insurance company. "We were surprised ... says Michael LaColla , CEO of Troubadour Research, ...
(Date:4/28/2016)... 2016 First quarter 2016:   ... with the first quarter of 2015 The gross margin ... (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) , ... unchanged, SEK 7,000-8,500 M. The operating margin for 2016 ...
(Date:4/15/2016)...  A new partnership announced today will help ... in a fraction of the time it takes ... life insurance policies to consumers without requiring inconvenient ... Diagnostics, rapid testing (A1C, Cotinine and HIV) and ... weight, pulse, BMI, and activity data) available at ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016 /PRNewswire/ - FACIT has announced the creation ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or "the ... a portfolio of first-in-class WDR5 inhibitors for the ... WDR5 represent an exciting class of therapies, possessing ... for cancer patients. Substantial advances have been achieved ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. is ... has received AOAC Research Institute approval 061601. , “This is another AOAC-RI approval ... Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods ...
(Date:6/23/2016)... --  EpiBiome , a precision microbiome engineering company, today ... from Silicon Valley Bank (SVB). The financing will allow ... drug development efforts, as well as purchase additional lab ... been an incredible strategic partner to us – one ... provide," said Dr. Aeron Tynes Hammack , EpiBiome,s ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... In a ... Hospital in Denmark detail how a patient who developed lymphedema after being treated for ... The results could change the paradigm for dealing with this debilitating, frequent side effect ...
Breaking Biology Technology:
Cached News: