HOME >> BIOLOGY >> NEWS
Researchers discover misfolded protein clumps common to dementia, Lou Gehrig's disease

Scientists have identified a misfolded, or incorrectly formed, protein common to two devastating neurological diseases, frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), according to a report in the Oct. 6, 2006, issue of Science. The findings suggest that certain forms of FTD, ALS and possibly other neurological diseases might share a common pathological process.

Virginia Lee, Ph.D., and John Trojanowski, M.D., Ph.D., of the University of Pennsylvania, led an international team of scientists in this discovery. The work was funded by the National Institute on Aging (NIA), part of the National Institutes of Health (NIH), and was done at the NIA-funded Alzheimer's Disease Center at the University of Pennsylvania School of Medicine Institute on Aging.

"This exciting basic science discovery provides the first molecular link between a dementia--FTD--and a motor neuron disease--ALS. It will advance understanding of the pathological processes of FTD and ALS, and possibly of other neurological disorders," says NIA director Richard J. Hodes, M.D. Improved understanding of underlying disease processes is critically important in pointing researchers toward the development of therapies for FTD, ALS and other neurodegenerative diseases, Hodes and the study authors note.

FTD affects the frontal and temporal lobes of the brain. People with FTD may exhibit uninhibited and socially inappropriate behavior, changes in personality and, in late stages, loss of memory, motor skills and speech. After Alzheimer's disease, it is the most common cause of dementia in people under age 65.

ALS is a progressive disease of brain and spinal cord motor neurons that control movement. Over time, walking, eating, speaking and breathing become more difficult in this fatal disease. Some people with ALS also have FTD, and some with FTD also develop ALS, suggesting that common mechanisms might underlie these t
'"/>

Contact: Linda Joy
nianews3@mail.nih.gov
301-496-1752
NIH/National Institute on Aging
5-Oct-2006


Page: 1 2

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/4/2019)... ... December 04, 2019 , ... NDA Partners Chairman ... a regulatory toxicology expert with more than 20 years of experience working in ... Dr. Todd has extensive experience with a variety of biologic modalities including monoclonal ...
(Date:12/2/2019)... ... 01, 2019 , ... Each year The Scientist ... the life-science landscape. For more than a decade, our expert panels of independent ... biological discovery. This year’s crop of entries to The Scientist’s Top 10 Innovations ...
(Date:11/27/2019)... ... November 26, 2019 , ... ... their Glen Ellyn, IL practice for Invisalign® treatment. Invisalign orthodontics uses ... Patients with a misaligned bite, also known as malocclusion, present both functional and ...
Breaking Biology News(10 mins):
(Date:12/30/2019)... TOWNSHIP, N.J. (PRWEB) , ... December 30, 2019 ... ... of custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device ... SIMS Version 1.11.19 21 CFR Part 11 compliant software program specific to the ...
(Date:12/27/2019)... , ... December 27, 2019 , ... ... studies for its 505(b)(2) product pipeline that offers patients and healthcare ... The products concepts were identified in collaboration with doctors and managed care professionals ...
(Date:12/18/2019)... SCOTTSDALE, Ariz. (PRWEB) , ... December 17, 2019 ... ... it has received its 31st FDA clearance for reprocessing Electrophysiology (EP) devices since ... where closest competitors, Stryker Sustainability Solutions and SterilMed (a Johnson & Johnson company) ...
(Date:12/18/2019)... ... December 18, 2019 , ... Tune in to CNBC ... by Ted Danson. Check local listings for more information on this program. , With ... reality are helping to simplify complex system to increase the efficiency, safety and effectiveness ...
Breaking Biology Technology:
Cached News: