HOME >> BIOLOGY >> NEWS
Researchers discover molecular mechanism that desensitizes us to cold

Mount Sinai School of Medicine researchers have discovered how the membrane protein that allows us to sense cold works and how this protein becomes desensitized so that one no longer feels the cold. The study, published this week as an advance online publication by Nature Neuroscience, focused on a specific region of the cold receptor which is found in many other receptors, including ones involved in taste, vision and fertilization. Therefore, the findings may have important implications across a wide range of areas.

Diomedes Logothetis, PhD, Dean of the Mount Sinai Graduate School of Biological Sciences, post-doctoral fellow Tibor Rohacs and colleagues studied the receptor that is responsible for the sensation of cold. They found that a specific region of this receptor interacts with a signaling lipid in the cell membrane called PIP2. Cold or menthol stimulate this receptor and alter the electrical properties of the membrane, a process that leads to the sensation of cold. When the receptor is stimulated, calcium enters the cell and stimulates the breakdown of PIP2. When PIP2 is broken down, the receptor becomes inactive, thus ending the sensation or desensitizing the cell to the cold stimulus.

"This finding provides critical information to help us understand how we sense heat and cold and from that to expand our understanding of temperature regulation," said Dr. Logothetis. "Additionally, because the region of this receptor that interacts with PIP2 is found in many similar membrane proteins, we now have a new lead in investigating regulation of the many functions in which these proteins are involved."

Many signals, such as neurotransmitters and growth factors are known to catalyze the breakdown of PIP2. Now that researchers know how PIP2 interacts with this large class of membrane proteins, they can begin to look out how these signals work and what effects they are having in various areas of the body.


'"/>

Contact: The Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
27-Apr-2005


Page: 1

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/7/2019)... ... 2019 , ... Concerto HealthAI, a technology leader in definitive ... and other key therapeutic areas, and its Chief Executive Officer, Dr. Jeff Elton, ... the entire healthcare landscape, on January 8, 2019, at 2:30 p.m. in San ...
(Date:1/4/2019)... ... ... Stay on top of current hot topics through free webinars presented by leading ... free, so be sure to register today to save your place! Participate in the ... our upcoming webinars, or click below to learn more about each webinar: , CLINICAL ...
(Date:12/20/2018)... ... December 20, 2018 , ... Human Factors and ... of a new usability/observation room. This addition will help meet the increased industry ... drug delivery devices/combination products are safe and easy to use when released to ...
Breaking Biology News(10 mins):
(Date:12/18/2018)... (PRWEB) , ... December 17, 2018 , ... ... today the second cohort of emerging biosciences ventures invited to participate in the ... education to develop fundable business plans and a professional network. All startups receive ...
(Date:12/13/2018)... Md. (PRWEB) , ... December 12, 2018 , ... ... and other life science software solutions, announces the Limfinity® ML (Machine Learning) addition ... integrate trained machine learning models within Limfinity® solutions. In the module, trained models ...
(Date:12/5/2018)... ... 05, 2018 , ... The incredible life story of former refugee and LG ... by Carlos Moedas, the European Commissioner for Research and Innovation. , In his ... Lives, Commissioner Moedas spoke at length of Yousef’s life and journey, citing the man ...
(Date:11/27/2018)... ... 27, 2018 , ... New patients in need of a dental crown ... with or without a referral. Dr. Myers has many years of experience improving patient ... bridges and custom crowns. , As a dedicated cosmetic dentist , Dr. ...
Breaking Biology Technology:
Cached News: