HOME >> BIOLOGY >> NEWS
Researchers discover molecular timekeeper in bone development

g through the bone-formation process, they discovered that the defect was in the earliest steps, where the cartilage foundation was being laid and filled with minerals. Before the foundation was complete, minerals were being deposited too soon, allowing bone to harden before it was ready.

Biochemical tests revealed that HDAC4 controls the early timing of osteogenesis by preventing the final step, bone hardening from occurring. By specifically blocking a protein called Runx2, which controls the genes for bone hardening, HDAC4 allows the foundation and minerals to be properly laid before hardening can occur.

Dr. Olson said he believes that calcium, which is required for healthy bones, may signal the release of HDAC4 from Runx2 to initiate the bone-hardening program.

"The discovery that bone formation is controlled by HDAC4, an enzyme, raises possibilities for designing drugs to control this process in the settings of bone diseases, such as osteoporosis," he said. "In fact, HDAC inhibitors are currently being used for the treatment of certain cancers. It will be interesting to investigate whether these inhibitors influence the process of bone formation."

Other UT Southwestern contributors to this study include Dr. Rick Vega, former postdoctoral researcher and lead author; Dr. James Richardson, professor of pathology and molecular biology; Dr. John Shelton, research scientist in internal medicine; Dr. Ana Barbosa, postdoctoral researcher in molecular biology; Dr. Junyoung Oh, former postdoctoral researcher in molecular biology; Eric Meadows and John McAnally, research technicians in molecular biology; Chris Pomajzl, former senior histology technician in pathology; and collaborators at Baylor College of Medicine.


'"/>

Contact: Amanda Siegfried
amanda.siegfried@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
11-Nov-2004


Page: 1 2

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... June 23, 2020 , ... First Aid Africa, a Scottish ... supplier and manufacturer of innovative portable renewable energy equipment, have announced the success ... the COVID-19 pandemic in Zambia. , One of Renovagen’s FAST FOLD portable solar ...
(Date:6/23/2020)... WOODLNDS, Texas (PRWEB) , ... June 23, 2020 ... ... X-ray analytical instrumentation, is pleased to announce the next event in a series ... X-ray scattering. , The TOPIQ series of webinars was developed in response to ...
(Date:6/19/2020)... ... ... The director of stem cell biotechnology company Asymmetrex , Dr. James ... industries have easier access to stem cell counting, they will soon make it a ... Day weekend in the U.S., Asymmetrex is offering free tissue stem cell counting at ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, ... its new tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes at ... requiring fast track capacity to provide patients with urgently needed vaccines and other ...
(Date:7/31/2020)... MIAMI (PRWEB) , ... July 29, 2020 , ... ... nearly 200 of the top radiation centers in 16 countries, has reached its ... years, SDX® is now in routine use at top universities including University of ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... aid in the early detection and prevention of high-burden diseases, and Centric Consulting, ... hospitals and healthcare organizations to utilize existing data in order to identify and ...
(Date:7/10/2020)... LEXINGTON, Mass. (PRWEB) , ... July 09, 2020 ... ... novel approaches to cell therapy, today announced the hiring of Allen R. Nissenson, ... executive team and oversee the clinical development of Sentien’s lead product, SBI-101. ...
Breaking Biology Technology:
Cached News: