Researchers discover stem cell 'guide' that may be key for targeting neural stem cell ...( smell part of the brain located above ...)

Researchers discover stem cell 'guide' that may be key for targeting neural stem cell treatments

smell" part of the brain located above the sinus cavity. PK2 allows these new neurons to settle into the proper areas of the olfactory bulb, thus permitting these neurons to function normally.

"Our findings identify one of the first endogenous guidance molecules for migrating neurons in the adult brain," Zhou said. "We are learning that molecules, like PK2, which direct the movement of neurons are crucial for neuronal replacement, and they demonstrate how adult stem cells might be manipulated for this process."

PK2 accomplishes this task by working with its corresponding cell receptors, which are part of the G protein-coupled receptor (GPCR) family. GPCRs are proteins found in a cell's membrane and play a critical role in transferring signals from outside of a cell to the molecular machinery within the cell. GPCRs are the largest family of proteins that serve as drug targets. It has been estimated that at least 40 percent of all medicines on the market act on this family of receptors.

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Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
23-Jun-2005

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