HOME >> BIOLOGY >> NEWS
Researchers extend mouse lifespan by protecting against free radicals

Scientists at the University of Washington and their colleagues at other research centers have found a way to significantly extend the lifespan of mice while reducing the impact of the aging process. Their study, which will be published online by the journal Science on May 5, lends more credence to the free-radical theory of aging.

The theory suggests that very reactive chemicals, called "free radicals," can be damaging to the body at the cellular level. Those reactive chemicals can take part in unnecessary chemical reactions that can damage the cell components, including DNA. Some researchers believe that free radicals could contribute to or hasten heart disease, cancer, and other age-related diseases. The theory also suggests that if the body could be protected from those free radicals, then age-related diseases could be tamed and organisms and ultimately people may be able to live longer.

Scientists have previously been able to extend the lifespan of mice in lab experiments by managing their diets and reducing their caloric intake. Another method relied on the restriction of a growth factor, but a side effect was that the mice suffered from dwarfism. However, neither of those methods of elongating the mouse lifespan was clearly connected to the free-radical theory of aging.

A group of scientists led by Dr. Peter Rabinovitch, professor of pathology at the UW School of Medicine, examined a method that was closely connected to the free-radical theory. He and his colleagues focused their study on catalase, an enzyme in the body that helps convert hydrogen peroxide into water and oxygen. Hydrogen peroxide is a waste product of metabolism and it can be a the precursor of free radicals that can damage the cell. The damage can in turn lead to more flaws in the cell's chemical processes, making a vicious cycle that leads to more free radicals, more cellular damage, and so on.

The researchers studied mice with a genetic variation that
'"/>

Contact: Justin Reedy
jreedy@u.washington.edu
206-685-0382
University of Washington
5-May-2005


Page: 1 2 3

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
(Date:10/29/2014)... compete with members of their own species. However, ... into their competitive ability. Some individuals are highly ... resources, while others seem to avoid competition, instead ... are left over for them. Moreover, the degree ... to fluctuate considerably over time. A theoretical study ...
(Date:10/28/2014)... in German . ... acquire sufficient food when times are lean? By studying ... d,Ivoire researchers of the Max Planck Institute for Evolutionary ... how great apes can acquire extra energy needed to ... their sleeping nests more en route to breakfast sites ...
(Date:10/28/2014)... be building a hybrid micro-grid which will integrate ... in the region, the hybrid micro-grid will test ... diesel, storage and power-to-gas technologies, and ensure these ... built under the new Renewable Energy Integration Demonstrator- ... located offshore at Semakau Landfill and is expected ...
Breaking Biology News(10 mins):Evolution of competitiveness 2Evolution of competitiveness 3The early chimp gets the fig 2The early chimp gets the fig 3NTU to build region's first renewable energy integration demonstration micro-grid 2NTU to build region's first renewable energy integration demonstration micro-grid 3
(Date:10/27/2014)... October 27, 2014 The “Molecular ... Genetics, Microbiology), Technology (PCR, INAAT, DNA Sequencing), End ... Service, Software) - Global Forecast to 2018” provides ... challenges, opportunities, current market trends, and strategies impacting ... estimates and forecasts of the revenue and share ...
(Date:10/27/2014)... , Oct. 27, 2014 Pressure BioSciences, ... worldwide leader in the development and sale of ... sciences research market, today announced that Professor ... novel, accurate, highly reproducible, and robust method to ... high-throughput protein analysis on small needle biopsy samples ...
(Date:10/26/2014)... The report "Protective Coatings Market by Resin Type, by ... to 2019", defines and segments the global protective coatings ... value generated. The protective coatings consumption is projected to ... by 2019, at a CAGR of 9.52% during the ... 22 figures spread through 219 slides and in-depth TOC ...
(Date:10/25/2014)... According to new market research ... Types (Colocation, Enterprise, Telecom), by Design Types (Electrical, ... 2, Tier 3, Tier 4) - Global Forecast ... the Data Center Construction Market into various segments ... This research report also identifies the factors driving ...
Breaking Biology Technology:Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 2Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 3Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 4Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 5Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 2Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 3Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 4Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 5Protective Coatings Market Poised to Reach $18,431.8 Million by 2019 - Report by MarketsandMarkets 2Protective Coatings Market Poised to Reach $18,431.8 Million by 2019 - Report by MarketsandMarkets 3Protective Coatings Market Poised to Reach $18,431.8 Million by 2019 - Report by MarketsandMarkets 4Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 2Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 3Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 4
Cached News: