HOME >> BIOLOGY >> NEWS
Researchers extend mouse lifespan by protecting against free radicals

Scientists at the University of Washington and their colleagues at other research centers have found a way to significantly extend the lifespan of mice while reducing the impact of the aging process. Their study, which will be published online by the journal Science on May 5, lends more credence to the free-radical theory of aging.

The theory suggests that very reactive chemicals, called "free radicals," can be damaging to the body at the cellular level. Those reactive chemicals can take part in unnecessary chemical reactions that can damage the cell components, including DNA. Some researchers believe that free radicals could contribute to or hasten heart disease, cancer, and other age-related diseases. The theory also suggests that if the body could be protected from those free radicals, then age-related diseases could be tamed and organisms and ultimately people may be able to live longer.

Scientists have previously been able to extend the lifespan of mice in lab experiments by managing their diets and reducing their caloric intake. Another method relied on the restriction of a growth factor, but a side effect was that the mice suffered from dwarfism. However, neither of those methods of elongating the mouse lifespan was clearly connected to the free-radical theory of aging.

A group of scientists led by Dr. Peter Rabinovitch, professor of pathology at the UW School of Medicine, examined a method that was closely connected to the free-radical theory. He and his colleagues focused their study on catalase, an enzyme in the body that helps convert hydrogen peroxide into water and oxygen. Hydrogen peroxide is a waste product of metabolism and it can be a the precursor of free radicals that can damage the cell. The damage can in turn lead to more flaws in the cell's chemical processes, making a vicious cycle that leads to more free radicals, more cellular damage, and so on.

The researchers studied mice with a genetic variation that
'"/>

Contact: Justin Reedy
jreedy@u.washington.edu
206-685-0382
University of Washington
5-May-2005


Page: 1 2 3

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/2/2016)... 2016 The Department of Transport Management ... 44 million US Dollar project, for the , ... Personalization, Enrolment, and IT Infrastructure , to ... and implementation of Identity Management Solutions. Numerous renowned international vendors ... Decatur was selected for the most compliant and ...
(Date:5/20/2016)... 2016  VoiceIt is excited to announce its ... By working together, VoiceIt and VoicePass will ... VoicePass take slightly different approaches to voice biometrics, ... and usability. ... partnership. "This marketing and technology partnership ...
(Date:4/28/2016)... FRANCISCO and BANGALORE, India , ... of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... provider, today announced a global partnership that will ... way to use mobile banking and payment services. ... is a key innovation area for financial services, but it ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ... its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced ... this eBook by providing practical tips, tools, and strategies for clinical researchers. , ...
(Date:6/23/2016)... , June 23, 2016 Houston Methodist ... the Cy-Fair Sports Association to serve as their ... agreement, Houston Methodist Willowbrook will provide sponsorship support, ... connectivity with association coaches, volunteers, athletes and families. ... the Cy-Fair Sports Association and to bring Houston ...
(Date:6/23/2016)... ... 23, 2016 , ... Supplyframe, the Industry Network for electronics ... Lab . Located in Pasadena, Calif., the Design Lab’s mission is to bring ... designed, built and brought to market. , The Design Lab is Supplyframe’s physical ...
(Date:6/23/2016)... Andrew D Zelenetz ... Published recently in Oncology ... touchONCOLOGY, Andrew D Zelenetz , discusses the ... is placing an increasing burden on healthcare systems ... With the patents on many biologics expiring, interest ...
Breaking Biology Technology:
Cached News: