HOME >> BIOLOGY >> NEWS
Researchers find level of special protein is critical to proper formation of muscles

GALVESTON, Texas -- Proper formation of the proteins that power heart and skeletal muscle seems to rely on a precise concentration of a "chaperone" protein known as UNC-45, according to a new study.

This basic discovery may have important implications for understanding and eventually treating heart failure and muscle wasting elsewhere in the body resulting from burns, brain trauma, diabetes, cancer and the effects of aging, the senior author of the paper said. The finding resulted from experiments using tiny, genetically engineered worms at the University of Texas Medical Branch at Galveston (UTMB), and is reported in a paper featured on the cover of the April 23, 2007, issue of the Journal of Cell Biology.

Chaperone proteins (known to biologists simply as chaperones) guide other newly formed proteins into the shapes that enable them to perform their specific functions.

In muscle cells, UNC-45 acts as a chaperone for myosin proteins, helping them fold into long, thin stable structures which clump together to form the thicker filaments that give heart and skeletal muscle its striated appearance. Chemical signals cause these myosin filaments to contract -- producing a heartbeat, for example, or an arm movement.

Scientists already knew that a shortage of UNC-45 disrupted myosin formation, leading to muscle paralysis. The reason: when there's not enough UNC-45 to go around, myosin proteins not yet in their final, stable form fall victim to a cellular cleanup squad called the ubiquitin/proteasome system (UPS), which breaks unstable (and presumably malfunctioning) proteins down into their amino acid components.

But the UTMB study, done using worms of the species Caenorhabiditis elegans (also known as C. elegans), showed that an over-supply of UNC-45 is also a problem.

"What we saw was that too much UNC-45 interfered with myosin accumulation and assembly," said Dr. Henry Epstein, chairman of UTMB's Department o
'"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
23-Apr-2007


Page: 1 2

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/1/2018)... ... August 01, 2018 , ... RURO, Inc., a ... version 7.1. Limfinity® is the software framework that all of RURO’s products are ... both current users and the future of RURO’s laboratory software portfolio. , To ...
(Date:8/1/2018)... ... 2018 , ... Visikol CEO Dr. Michael Johnson has announced that through the ... Visikol will far exceed its original 2018 revenue projections. , Over the last ... pathology tools, whole mount imaging techniques and advanced 3D cell ...
(Date:7/31/2018)... ... July 31, 2018 , ... ... Muzek as Business Development Manager. In this role, Mr. Muzek will lead the ... Lifecycle’s continued growth and expansion. , With over 20 years in business ...
Breaking Biology News(10 mins):
(Date:8/9/2018)... ... August 08, 2018 , ... ActX ... and is continually updated by a talented scientific team that includes geneticists, PharmD’s, ... , 1. Information on the medical impact of a patient’s genetic variants ...
(Date:8/9/2018)... ... August 09, 2018 , ... ... Rockland, and Dr. Birte Aggeler, Director of Antibody Development at Bio-Techne, composed a ... article was published online on August 9, 2018 and will be printed in ...
(Date:8/1/2018)... (PRWEB) , ... August 01, ... ... healer, today announces research results on the significant impact of a proprietary ... responses. , The preclinical research assessed biomarkers for systemic and organ-specific ...
(Date:7/27/2018)... ... July 27, 2018 , ... ... Advocacy Group (BRAG®) and representatives of the Biotechnology Innovation Organization (BIO) met ... recently-issued white paper, “Proposal for a Toxic Substances Control Act (TSCA) Inventory ...
Breaking Biology Technology:
Cached News: