HOME >> BIOLOGY >> NEWS
Researchers find new technique to identify fetal genetic material from amniotic fluid

A preliminary report suggests that cell-free fetal messenger RNA (ribonucleic acid) can be extracted from amniotic fluid (fluid around the fetus), and then be analyzed to study gene expression changes that may reflect the well-being of the fetus, according to a paper in the February 16 issue of JAMA, a theme issue on medical applications of biotechnology.

In background information in the article, the authors write that fetal monitoring in the womb is now "limited to noninvasive methods such as measurement of uterine size or anatomic evaluation by fetal sonography. In addition, genetic analysis can be performed on amniotic fluid components " They add that the "cell-free component of the amniotic fluid is discarded after these analyses and is therefore available for research and future clinical applications."

Paige B. Larrabee, M.D., from Tufts-New England Medical Center, Boston, and colleagues analyzed four samples of cell-free amniotic fluid from pregnant women between 20 and 32 weeks' gestation and who had certain conditions that required procedures to reduce an excessive amount of amniotic fluid. The control group in this study was 6 pooled amniotic fluid samples from women at 17 weeks' gestation who were undergoing amniocentesis (removal of amniotic fluid to test for hereditary diseases and congenital defects in the fetus). "After extraction from the normally discarded fraction of amniotic fluid, RNA was amplified twice, labeled, and analyzed using gene expression microarrays." The researchers were able to study the expression of developmental transcripts, such as for certain proteins.

"Preliminary analysis suggests that gene expression changes can be detected in fetuses of different sexes, gestational age, and disease status," the authors report. "Cell-free mRNA in amniotic fluid appears to originate from the fetus and not the placenta." In conclusion the authors write: "The intriguing gene expression differences observed suggest
'"/>

Contact: Melissa McPherson
617-636-3265
JAMA and Archives Journals
15-Feb-2005


Page: 1 2

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/2/2018)... ... October 02, 2018 , ... The Federal Identity Forum & ... Convention Center. The Palo Alto-based face recognition company, Camvi Technologies Inc., was invited ... speakers included U.S. Federal executives from Department of Defense (DoD) and Federal Bureau ...
(Date:10/1/2018)... ... October 01, 2018 , ... Myoscience, Inc. ... Chief Executive Officer. Mr. Still will also be joining the Company’s Board of ... devices and diagnostics. He has extensive leadership experience in designing and implementing highly ...
(Date:10/1/2018)... ... 2018 , ... Despite U.S. nursing and assisted living facilities ... facilities are dire. Lawsuits dot the news landscape including the 2017 class-action lawsuit ... and profit-driven approach” has had “devastating” consequences for its California residents, who were ...
Breaking Biology News(10 mins):
(Date:10/2/2018)... ... October 02, 2018 , ... Finalists for the ... Bio-Energy) AssurEOR product line was chosen for its advancements in the production chemicals ... leading innovations in upstream oil applications that are positively impacting the industry. The ...
(Date:9/29/2018)... ... September 29, 2018 , ... Voxx Analytics ... companies to access the power of influence analytics and data-driven engagement decision making. ... broader market that didn’t necessarily have access to the same financial resources as ...
(Date:9/27/2018)... ... September 26, 2018 , ... NDA Partners Chairman ... senior quality, regulatory, and in vitro diagnostic device expert with more than 28 ... joined the firm as an Expert Consultant. Her experience includes leadership roles in ...
(Date:9/27/2018)... ... September 26, 2018 , ... ... its focus® Pedicle Screw System today at the North American Spine Society (NASS) ... , The Nvision focus Pedicle Screw System, which received clearance from the U.S. ...
Breaking Biology Technology:
Cached News: