HOME >> BIOLOGY >> NEWS
Researchers find pathway that controls cell size and division

Organisms precisely regulate cell size to ensure that daughter cells have sufficient cellular material to thrive or to create specific cell types: a tiny sperm versus a gargantuan egg for example. In single-celled organisms such as yeast and bacteria nutrient availability is the primary determinant of cell size. In animal cells size is controlled in large part by a molecule that senses the blood sugar dependent hormone insulin.

Petra Levin, Ph.D., Assistant Professor of Biology at Washington University in St. Louis, and her laboratory have recently identified a trio of enzymes that act in concert to link nutrient availability to cell size in the soil bacterium Bacillus subtilis.

Levin and her lab are looking into the factors that control the timing and position of cell division in B. subtilis. B. subtilis serves as the model system for a large family of bacteria that includes the causative agents of several important diseases, including anthrax and botulism. By learning how these simple organisms regulate division, we can better understand why this process goes awry in cancer cells resulting in uncontrolled growth and aberrant division.

A primary focus of the Levin labs research is a protein called FtsZ. FtsZ is an ancestor of tubulin, the protein that is responsible for distributing duplicated chromosomes between dividing human cells. In bacteria, FtsZ forms a ring at the future division site. The FtsZ ring then recruits all other components necessary for cell division and serves as the scaffolding for the entire division process.

The factors that regulate FtsZ ring formation determine when and where the cell is going to divide. Theoretically a cell could divide anywhere and at anytime, said Brad Weart, a graduate student in Levins lab. The cell has to very precisely restrain that process so that it only happens when and where the cell wants it to happen.

In their most recent paper, published in the July 27, 20
'"/>

Contact: Tony Fitzpatrick
tony_fitzpatrick@wustl.edu
314-935-5272
Washington University in St. Louis
30-Jul-2007


Page: 1 2 3

Related biology news :

1. Researchers watch antibiotics, bacteria meet at atomic level
2. Researchers discover gene responsible for Restless Legs Syndrome
3. Researchers witness natural selection at work in dramatic comeback of male butterflies
4. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
5. Researchers use new approach to predict protein function
6. Researchers probe risks, benefits of folic acid fortification
7. Researchers identify genetic mutation that may alter tumor cell proliferation
8. Researchers discover method for identifying how cancer evades the immune system
9. Researchers use adult stem cells to create soft tissue
10. Researchers find gene that spurs development of the epididymis
11. Researchers isolate new risk marker for overweight children

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/20/2017)... 2017 PMD Healthcare announces the release of ... Management System (WMS), a remote, real-time lung health monitoring ... Healthcare is a Medical Device, Digital Health, and Chronic ... creating innovative solutions that empower people to improve their ... PMD developed the first ever personal spirometer, Spiro PD, ...
(Date:3/9/2017)... March 9, 2017 4Dx has publicly released ... Imaging Workshop at the University of Pennsylvania. Founder and ... deliver the latest data to world leaders in lung ... together leaders at the forefront of the industry to ... "The quality of the imaging is ...
(Date:3/7/2017)...   HireVue , the leading provider of video ... best talent, faster, today announced the additions of ... Diana Kucer as Chief Marketing Officer (CMO). ... poised to drive continued growth in the company,s new ... record bookings in 2017. "Companies worldwide turn ...
Breaking Biology News(10 mins):
(Date:4/21/2017)... ... 2017 , ... Having worked on the design of the innovative Triton™ ... to top lab design architects from around the country at the Lab Design Conference ... and Engineering Greg Casey will be at the show, where they will highlight the ...
(Date:4/21/2017)... ... April 21, 2017 , ... The AMA is happy to announce ... from across the nation. The scholarships are created through funds donated by model aviation ... criteria are set by the AMA Scholarship Committee, which is made up of model ...
(Date:4/20/2017)... ... April 20, 2017 , ... As part ... will explore challenging patient cases when screening for direct oral anticoagulant. When patients ... a need for bridging parental anticoagulation especially for those at high risk of ...
(Date:4/20/2017)... ... , ... USDM Life Sciences , the leading risk management, technological innovation ... to announce Holger Braemer as Vice President of its Europe division and ... , Braemer is an integral part of USDM’s expansion of services and solutions ...
Breaking Biology Technology:
Cached News: