Researchers find two biomarkers with potential to predict breast can...( show over-production of 4871 Da compa...)

Researchers find two biomarkers with potential to predict breast cancer spread

show over-production of 4,871 Da, compared to patients with no lymph node spread. The peak at 4,871 could also predict patients with four or more metastatic nodes who have significantly worse outcomes.

Although they dont know what these proteins are, by searching a protein database Hoon suggests that 4,871 Da may represent thymosin beta-10, a peptide that has already been associated with out-of-control growth and cell differentiation, and that 8,596 Da could represent an ubiquitin protein associated with a good prognosis in node-negative breast cancer.

"Protein peaks found in our study may be useful as prognostic biomarkers, but we must be cautious until the identities of these proteins are known and validated in a larger study," Hoon said.

Contact: Staci Vernick Goldberg
goldberg@aacr.org
215-440-9300
American Association for Cancer Research
15-Dec-2006

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