HOME >> BIOLOGY >> NEWS
Researchers identify key step in cocaine-induced heart enlargement, sudden death

Tampa, FL (Sept. 7, 2006) -- Cocaine, in concentrations commonly sold on the street, causes the abnormal buildup of primitive proteins in heart muscle a process causing heart enlargement that can ultimately lead to sudden death, report researchers at the University of South Florida College of Medicine and James A. Haley Veterans' Hospital.

The study was published in the July 2006 issue of the Journal of Cardiovascular Pharmacology.

"This finding is important because cocaine-related deaths most commonly occur in young people between the ages of 18 and 29, many of whom are totally unaware of the drug's toxic effects," said Robert Henning, MD, professor of medicine at the USF College of Medicine at the Haley VA Hospital.

Using heart muscle cells from adult rats, Dr. Henning and his colleagues found that cocaine activates the enzyme calmodulin kinase II (CaMK), which increases calcium within the heart muscle cells. The increase in calcium appears to be a key step in prompting the accumulation of primitive fetal proteins not normally found in adult heart muscle cells a process that causes the muscles cells, and eventually the heart, to enlarge. It also triggers irregular heart rhythms that can cause sudden death.

The researchers also demonstrated that the CaMK inhibitors Nifedipine and KN-62 appear to limit the accumulation of abnormal proteins in heart muscle, suggesting they may be a useful therapy for cardiac hypertrophy, or enlarged heart.

The USF researchers' findings may also have wider implications for other forms of heart enlargement caused by chronic disease. "The biomolecular pathway that we've identified likely also plays an important role in heart hypertrophy due to hypertension, heart attacks and heart failure," Dr. Henning said.

In cardiac hypertrophy, or enlarged heart, the heart's main pumping chamber becomes abnormally large as a result of an increased workload. In time, fibers of the he
'"/>

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3300
University of South Florida Health
7-Sep-2006


Page: 1 2

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/22/2018)... ... December 21, 2018 , ... ... and hosted the Boston Healthcare Drinks event featuring Helen Chen, Greater China Managing ... China.” , The discussion was moderated by patent attorney David J. Dykeman ...
(Date:12/19/2018)... (PRWEB) , ... December 19, 2018 , ... InTouchMD’s flagship ... innovative products in healthcare for 2018. , PM360 is featuring the recognition in ... products and services offered to the pharmaceutical and medical device industries. , “This ...
(Date:12/18/2018)... ... December 18, 2018 , ... ... cancers and other serious diseases, today announced the publication of an early feasibility ... treatment of rGBM. , The publication of the study, An Early Feasibility ...
Breaking Biology News(10 mins):
(Date:1/7/2019)... ... January 07, 2019 , ... Kainos Medicine Inc. today announced ... candidate, code-named "KM-819." KM-819 is an orally active small molecule that is ... Korea. , This Phase 1 randomized, double-blind, placebo-controlled dose-escalation study was to ...
(Date:12/20/2018)... ... December 20, 2018 , ... New Year’s brings reflection and desire to improve ... the European Union (EU) on the horizon, Jim Kasic, president and CEO of Boulder ... the EU Medical Device Regulation (MDR), digital health, and big data are just a ...
(Date:12/18/2018)... ... ... Patients with early stages of breast cancer who undergo partial breast proton ... irradiation, a new study suggests. , Patients with early stage breast cancer — stage ... the cancerous tumor because there is a 30 to 40 percent change the disease ...
(Date:12/13/2018)... ... December 13, 2018 , ... Microbial Discovery Group LLC (MDG) ... been part of their strategic plan and an important milestone in increasing their ... opportunities for MDG within the $44 Billion human probiotic market. This plan is ...
Breaking Biology Technology:
Cached News: