HOME >> BIOLOGY >> NEWS
Researchers identify taste receptor responsible for caffeine detection

By studying how taste-receptor mutations impact fruit fly behavior, researchers have identified a taste receptor responsible for the detection of caffeine, a bitter compound known to activate certain taste-receptor neurons, as well as impact various aspects of physiology. The findings are reported by Craig Montell and colleagues at Johns Hopkins University, and appear in the September 19th issue of Current Biology, published by Cell Press.

Many proteins have been identified in mammals and in the genetic model organism Drosophila that belong to a large family of taste receptors, but relatively few of these receptors have been shown to be responsible for the detection of a specific taste compound, or "tastant." One class of tastants for which receptors have not yet been identified is methylxanthines, which include caffeine and related compounds in tea (theophylline) and cocoa (theobromine).

In the new work reported by Montell and colleagues, researchers showed that a specific taste receptor, known as Gr66a, is responsible for the perception of caffeine's bitter taste by fruit flies. The researchers showed that when the gene encoding the Gr66a receptor was disrupted, the mutant flies failed to react normally to the presentation of caffeine, which is a bitter compound that is aversive to flies. Flies with an intact Gr66a receptor gene strongly prefer to consume sucrose (sugar) when given a choice between sucrose and a mixture of sucrose and bitter compounds, but the researchers showed that flies bearing a mutation that disrupted Gr66a failed to show this strong propensity when the bitter mixture contained caffeine. The researchers also showed that activation of the gustatory-receptor neurons that express the Gr66a receptor was impaired in the mutants: Although these gustatory neurons were activated normally by a range of different tastants, they failed to be activated by caffeine, or by the related methylxanthine, theophylline. Another methylxanthin
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
18-Sep-2006


Page: 1 2

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
(Date:7/24/2014)... your gut that has gone undetected by scientists for ... Diego State University has found that more than half ... virus, named crAssphage, which infects one of the most ... phylum of bacteria is thought to be connected with ... today in Nature Communications ., Robert A. Edwards, ...
(Date:7/23/2014)... -- Pfenex Inc. (NYSE MKT: PFNX) today announced the pricing ... common stock at a price to the public of $6.00 ... 30-day option to purchase up to 1,250,000 additional shares of ... are expected to begin trading on the NYSE MKT on ... William Blair & Company, L.L.C. and JMP Securities LLC ...
(Date:7/23/2014)... new study of identical twins has found that early ... study, in the journal Child Development , was ... King,s College London. , "Since reading is an ability ... reading instruction," according to Stuart J. Ritchie, research fellow ... the study. "Early remediation of reading problems might aid ...
Breaking Biology News(10 mins):Newly discovered gut virus lives in half the world's population 2Newly discovered gut virus lives in half the world's population 3Pfenex Inc. Announces Pricing Of Initial Public Offering 2Stronger early reading skills predict higher intelligence later 2
(Date:7/23/2014)... (MIPT and Russian Quantum Center at Skolkovo) and ... and the Institute of Physics in Bratislava, Slovakia) ... of particles passing through an amplifier and, conversely, ... are provided in an article published in the ... , Quantum entangled particles are considered to be ...
(Date:7/23/2014)... 2014 Last year, Formedix ... leading global provider of data management solutions for clinical ... leading-edge system for electronic data capture (EDC) and clinical ... and study execution tools added TrialMaster to its Transform ... version of Transform for TrialMaster, is being released this ...
(Date:7/23/2014)... July 23, 2014 DuPont Pioneer announced ... as vice president of Agricultural Biotechnology (ABT), effective July ... he served most recently as president, chief executive officer ... business leadership in the seed and crop protection industry ... Paul E. Schickler , president of DuPont Pioneer. “I ...
(Date:7/23/2014)... , July 23, 2014  Sofinnova Ventures, a ... announced the closing of Sofinnova Venture Partners IX, L.P. ... excess of the initial fund target of $425 million. ... successful biotechnology companies. Consistent with recent funds, SVP IX ... stage clinical programs, along with select investments in earlier ...
Breaking Biology Technology:Scientists find way to maintain quantum entanglement in amplified signals 2Scientists find way to maintain quantum entanglement in amplified signals 3Scientists find way to maintain quantum entanglement in amplified signals 4Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 2Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 3DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 3Sofinnova Raises $500 Million Biotech Venture Fund 2
Cached News: