Researchers identify taste receptor responsible for caffeine detection

By studying how taste-receptor mutations impact fruit fly behavior, researchers have identified a taste receptor responsible for the detection of caffeine, a bitter compound known to activate certain taste-receptor neurons, as well as impact various aspects of physiology. The findings are reported by Craig Montell and colleagues at Johns Hopkins University, and appear in the September 19th issue of Current Biology, published by Cell Press.

Many proteins have been identified in mammals and in the genetic model organism Drosophila that belong to a large family of taste receptors, but relatively few of these receptors have been shown to be responsible for the detection of a specific taste compound, or "tastant." One class of tastants for which receptors have not yet been identified is methylxanthines, which include caffeine and related compounds in tea (theophylline) and cocoa (theobromine).

In the new work reported by Montell and colleagues, researchers showed that a specific taste receptor, known as Gr66a, is responsible for the perception of caffeine's bitter taste by fruit flies. The researchers showed that when the gene encoding the Gr66a receptor was disrupted, the mutant flies failed to react normally to the presentation of caffeine, which is a bitter compound that is aversive to flies. Flies with an intact Gr66a receptor gene strongly prefer to consume sucrose (sugar) when given a choice between sucrose and a mixture of sucrose and bitter compounds, but the researchers showed that flies bearing a mutation that disrupted Gr66a failed to show this strong propensity when the bitter mixture contained caffeine. The researchers also showed that activation of the gustatory-receptor neurons that express the Gr66a receptor was impaired in the mutants: Although these gustatory neurons were activated normally by a range of different tastants, they failed to be activated by caffeine, or by the related methylxanthine, theophylline. Another methylxanthin

Contact: Heidi Hardman
Cell Press

Page: 1 2

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:

(Date:11/19/2015)... -- Although some 350 companies are actively involved in molecular ... according to Kalorama Information. These include Roche Diagnostics, Hologic, Abbott ... of the 6.1 billion-dollar molecular testing market, according to ... Diagnostic s .    ... one company and only a handful of companies can ...
(Date:11/17/2015)... Paris , qui ... Paris , qui s,est tenu du ... leader de l,innovation biométrique, a inventé le premier scanner ... sur la même surface de balayage. Jusqu,ici, deux scanners ... les empreintes digitales. Désormais, un seul scanner est en ...
(Date:11/12/2015)... 2015  A golden retriever that stayed healthy despite ... has provided a new lead for treating this muscle-wasting ... Institute of MIT and Harvard and the University of ... Cell, pinpoints a protective gene that ... effects. The Boston Children,s lab of Lou Kunkel ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... 2015 --> ... "Oligonucleotide Synthesis Market by Product & Services (Primer, Probe, ... DNA, RNAi), End-User (Research, Pharmaceutical & Biotech, Diagnostic Labs) ... market is expected to reach USD 1,918.6 Million by ... CAGR of 10.1% during the forecast period. ...
(Date:11/24/2015)... 24, 2015 SHPG ) announced today that ... Piper Jaffray 27 th Annual Healthcare Conference in ... at 8:30 a.m. EST (1:30 p.m. GMT). --> SHPG ... will participate in the Piper Jaffray 27 th Annual Healthcare ... Tuesday, December 1, 2015, at 8:30 a.m. EST (1:30 p.m. GMT). ...
(Date:11/24/2015)... CITY , Nov. 24, 2015 /PRNewswire/ - ... "Company") announced today that the remaining 11,000 post-share ... Share Purchase Warrants (the "Series B Warrants") subject ... were exercised on November 23, 2015, which will ... Shares.  After giving effect to the issuance of ...
(Date:11/24/2015)... ... November 24, 2015 , ... InSphero AG, the leading supplier of ... has promoted Melanie Aregger to serve as Chief Operating Officer. , Having ... management team and was promoted to Head of InSphero Diagnostics in 2014. ...
Breaking Biology Technology:
Cached News: