HOME >> BIOLOGY >> NEWS
Researchers learn how blood vessel cells cope with their pressure-packed job

UCSD researchers stretched cells in a workout chamber the size of a credit card to gain a better understanding of how repetitive stretching of endothelial cells that line arteries can make them healthy and resistant to vascular diseases.

Bioengineering researchers at UCSD's Jacobs School of Engineering will report in the Nov. 1 issue of Proceedings of the National Academy of Sciences (PNAS) that arterial endothelial cells subjected to repeated stretching (10 percent of their length, 60 times per minute) produced intracellular arrays of parallel "stress fibers" in a few hours.

The tests were performed on endothelial cells lining the aorta of a cow, but the endothelial cells of the human aorta are expected to react similarly. The stress fibers were made of actin, a fibrous protein that is part of the machinery that gives muscle its ability to contract. Actin also gives virtually all cells their ability to make an internal "cytoskeleton." The stress fibers of endothelial cells in arteries are aligned parallel to the long axis of blood vessels, and this alignment is perpendicular to the direction of rhythmic stretching caused by a beating heart. Such an orientation of stress fibers is a hallmark of healthy blood vessels, but scientists currently understand few of the factors responsible for generating that configuration.

Rubber bands and most other flexible materials react to stretching by forming stress wrinkles parallel to the direction in which they are being pulled. However, the healthy bovine aorta endothelial cells did not behave that way in tests performed in the laboratory of Shu Chien, a coauthor of the PNAS paper and a professor of bioengineering and medicine and director of the Whitaker Institute of Biomedical Engineering at UCSD. When Chien and his collaborators stretched the cells back and forth along one axis in the miniature workout chambers, the cells formed stress fibers perpendicular to the direction of stretch. "This orientation o
'"/>

Contact: Rex Graham
ragraham@ucsd.edu
858-822-3075
University of California - San Diego
24-Oct-2005


Page: 1 2 3

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/4/2017)... 2017   EyeLock LLC , a leader of ... States Patent and Trademark Office (USPTO) has issued U.S. ... of an iris image with a face image acquired ... company,s 45 th issued patent. ... given the multi-modal biometric capabilities that have recently come ...
(Date:3/29/2017)...  higi, the health IT company that operates the ... , today announced a Series B investment from ... The new investment and acquisition accelerates higi,s strategy to ... population health activities through the collection and workflow integration ... collects and secures data today on behalf of over ...
(Date:3/23/2017)... 23, 2017 The report "Gesture Recognition and Touchless Sensing ... Geography - Global Forecast to 2022", published by MarketsandMarkets, the market is expected ... 29.63% between 2017 and 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:7/18/2017)... ... July 18, 2017 , ... Allotrope Foundation ... the first phase of the Allotrope Framework for commercial use. , The Bio-IT ... to “not only elevate the critical role of information technology in modern biomedical ...
(Date:7/17/2017)... Pa. (PRWEB) , ... July ... ... provider of technology-enabled clinical trial solutions, today announced safety software company AB ... within the eHealth Solutions business segment to advance technology innovation across life ...
(Date:7/17/2017)... City, Utah (PRWEB) , ... July 17, 2017 ... ... a molecular diagnostics company that has developed and intends both to manufacture and ... started trading on the NASDAQ Capital Market. , Headquartered in Sandy, Utah, Co-Diagnostics’ ...
(Date:7/15/2017)... ... July 15, 2017 , ... Cuvette manufacturer FireflySci has been ... time, the people at FFS have learned that their biggest asset was their amazing ... able to launch new products to meet the changing needs of scientists at a ...
Breaking Biology Technology:
Cached News: