HOME >> BIOLOGY >> NEWS
Researchers map genome of deadly fungus

ST. LOUIS -- Following a long-term collaborative effort, scientists have deciphered the genomes of two strains of a fungus that can lead to brain swelling and death in those with compromised immune systems.

Results were published at 2 p.m. Jan. 13 in the online "express" version of the journal Science: http://www.sciencemag.org/sciencexpress/recent.shtml

The fungus, which causes severe inflammation of the brain, is called Cryptococcus neoformans (C. neoformans). It is estimated that about 15 percent of people with HIV will suffer at least one life-threatening infection; the figure may reach as high as 40 percent in Africa. Those taking chemotherapy drugs, steroid treatments or drugs to prevent rejection of a transplanted organ also are susceptible to infection.

Jennifer Lodge, Ph.D., a biochemist and associate dean of research at Saint Louis University School of Medicine, was head of the steering committee for the Cryptococcus Genome Project a group formed in 1999 to map the genome of two common strains of this fungus.

"This research will be an enormous factor in developing treatments for C. neoformans infection, which is a major problem for those with compromised immune systems," Lodge said. "We've discovered several unique attributes that point to new ways to attack the fungus and cure infection."

For instance, the C. neoformans develops a unique polysaccharide capsule that envelops the fungus and aids in biosynthesis. Because the study identified about 30 new genes that likely are involved in this process, scientists now could find ways to interfere with the process and stop infection.

Researchers also identified differences between a highly virulent strain of C. neoformans and one that doesn't cause severe infection. These differences may hold the key to understanding why this particular fungus is so viru
'"/>

Contact: Matt Shaw
shawmr@slu.edu
314-977-8018
Saint Louis University
13-Jan-2005


Page: 1 2

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/12/2020)... ... August 11, 2020 , ... Both Roche, based ... entered into license agreements with Housey Pharma’s HMI subsidiary to gain access to ... have annual Research and Development spending in excess of US $10 billion. , ...
(Date:8/7/2020)... FRANCISCO (PRWEB) , ... August 06, 2020 , ... ... life sciences industry, is pleased to announce that Eric Chen and Jessica Wong ... President of Product Management & Strategy, respectively. , Eric Chen heads development efforts ...
(Date:8/5/2020)... ... August 05, 2020 , ... Regenative Labs has received approval ... CoreText™ and ProText™, making them the first Wharton’s jelly allografts to be assigned a ... The company’s solutions are the first Wharton’s jelly allograft product to be recognized as ...
Breaking Biology News(10 mins):
(Date:7/22/2020)... ... 22, 2020 , ... Join experts from Reed Tech , Gary Saner, ... a one hour live webinar on Thursday, August 13, 2020 at 11am ... and medical devices. Specifically, for medical devices, the NMPA has departments dealing with medical ...
(Date:7/10/2020)... (PRWEB) , ... July 08, 2020 , ... ... services and products, announces a significant expansion of laboratory operations through its ... for agencies implementing testing programs. , Bode-CARES provides a turnkey ...
(Date:7/7/2020)... , ... July 06, 2020 , ... ... Awards. Entries from Roche, Eli Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts ... Bio-IT World has hosted an elite awards program, highlighting outstanding examples of how ...
(Date:6/28/2020)... ... June 25, 2020 , ... With the COVID-19 ... or drug treatment. In an effort to better understand the cellular responses to ... largest imaging dataset portraying therapeutic compound effects from over 1,600 approved and referenced ...
Breaking Biology Technology:
Cached News: